Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

被引：117

作者：

Bagherifard, Sara ^{[1
,2
,3
,4
]}

Tamayol, Ali ^{[1
,2
,5
]}

Mostafalu, Pooria ^{[6
]}

Akbari, Mohsen ^{[1
,2
,5
,7
]}

Comotto, Mattia ^{[1
,2
]}

Annabi, Nasim ^{[1
,2
,5
,8
]}

Ghaderi, Masoumeh ^{[1
,2
]}

Sonkusale, Sameer ^{[6
]}

Dokmeci, Mehmet R. ^{[1
,2
,5
]}

Khademhosseini, Ali ^{[1
,2
,5
,9
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Biomat Innovat Res Ctr,Dept Med, Cambridge, MA 02139 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[4] Politecn Milan, Dept Mech Engn, I-20156 Milan, Italy

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[6] Tufts Univ, Dept Elect & Comp Engn, Nanoscale Integrated Sensors & Circuits Lab Nanol, Medford, MA 02155 USA

[7] Univ Victoria, Dept Mech Engn, Victoria, BC V8W 2Y2, Canada

[8] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[9] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

来源：

ADVANCED HEALTHCARE MATERIALS | 2016年 / 5卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CONTROLLED-RELEASE; PLGA NANOPARTICLES; ELECTRONICS; HYDROGELS; MICROPARTICLES; MICROCAPSULES; DESIGN;

D O I：

10.1002/adhm.201500357

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications.

引用

页码：175 / 184

页数：10

共 40 条

[21] Hydrogels in controlled release formulations: Network design and mathematical modeling [J].