New glycosyl-(carboxamide)-1,2,3-triazole-N-nucleosides:: Synthesis and antitumor activity

被引：18
作者：
Al-Masoudi, NA
Al-Soud, YA
机构：
[1] Univ Konstanz, Fac Chem, D-78434 Constance, Germany
[2] Univ Al Al Bayt, Coll Sci, Dept Chem, Al Mafraq, Jordan
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2002年 / 21卷 / 4-5期
关键词：
D O I：
10.1081/NCN-120006830
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of potential bioactive compounds, 1-glucopyranosyl-1,2,3-triazole-4,5-dimethylcarboxylate, 1-glucopyranosyl-1,2,3-triazole-4,5-N-dicarbox-amide,-dialkyl-dicarboxamide-N-nucleosides and 6-amine-4H-1-(beta-D-glucopyranosyl)-8-hydroxy-1,2,3-triazolo[4,5-e][1,3]-diazepin-4-one, were synthesized. Primary activity screening of the novel nucleosides showed poor or no anticancer activity against breast, lung and CNS tumors.
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收藏
页码：361 / 375
页数：15
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