Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease

被引：26

作者：

Hansson, Oskar ^{[1
,2
]}

Cullen, Nicholas ^{[2
,3
]}

Zetterberg, Henrik ^{[4
,5
,6
,7
]}

Blennow, Kaj ^{[4
,5
]}

Mattsson-Carlgren, Niklas ^{[2
,3
,8
]}

机构：

[1] Skane Univ Hosp, Memory Clin, SE-20502 Lund, Sweden

[2] Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden

[3] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden

[4] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[5] Gothenburg Univ, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden

[6] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[7] UCL, UK Dementia Res Inst, London, England

[8] Skane Univ Hosp, Dept Neurol, Lund, Sweden

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2021年 / 8卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 欧洲研究理事会; 瑞典研究理事会; 加拿大健康研究院;

关键词：

NEUROIMAGING INITIATIVE ADNI; BIOMARKER;

D O I：

10.1002/acn3.51253

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer's disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer's disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolism and cortical atrophy at baseline and over time, and longitudinally increased tau was associated with accelerated atrophy, but these associations were only observed in A beta-positive participants. Plasma phosphorylated tau may identify and track processes linked to neurodegeneration in Alzheimer's disease.

引用

页码：259 / 265

页数：7

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