Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk An Independent Study in Han Chinese

被引:11
|
作者
Zhang, Haiyan [1 ,2 ]
Zhang, Zhen [2 ]
Li, Guang [3 ]
Wang, Surong [4 ]
Zhang, Shiqian
Xie, Beibei [2 ]
机构
[1] Shandong Univ, Qilu Hosp, Dept Gynecol, Jinan 250100, Peoples R China
[2] Linyi City Peoples Hosp, Gynecol Ward 1, Linyi 276000, Shandong, Peoples R China
[3] Linyi City Peoples Hosp, Dept Gastrointestinal Surg, Linyi 276000, Shandong, Peoples R China
[4] Linyi City Peoples Hosp, Gynecol Ward 3, Linyi 276000, Shandong, Peoples R China
关键词
FC RECEPTOR HOMOLOGS; NF-KAPPA-B; RHEUMATOID-ARTHRITIS; DISEASE; SUSCEPTIBILITY; PATHOGENESIS; WOMEN; IDENTIFICATION; POPULATION; ACTIVATION;
D O I
10.1097/MD.0000000000001168
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The Fc receptor-like 3 (FCRL3) gene was reported to be linked to a variety of autoimmune diseases, including endometriosis-related infertility. However, this linkage has not been studied in Chinese population and there has been no meta-analysis on the interrelationship of FCRL3 gene and endometriosis-related infertility. The aim of the study was to investigate the association between FCRL3 genetic polymorphisms and the risk of endometriosis-related infertility in Han Chinese, and a further meta-analysis was conducted to confirm our results.Four single nucleotide polymorphisms (SNPs) (rs7528684 [FCRL3_3], rs11264799 [FCRL3_4], rs945635 [FCRL3_5], and rs3761959 [FCRL3_6]) on FCRL3 gene were genotyped in a case-control cohort composed of 217 patients suffering from endometriosis-related infertility and 220 healthy controls using cleaved amplification polymorphism sequence-tagged sites (polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP). Odds ratio (OR) and its 95% confidence interval (CI) was used to evaluate the association quantitatively. Furthermore, a meta-analysis of previous studies including the present study was implemented through Stata 11.0 (Stata Corporation, College Station, TX).We found an approximately 1.4-fold significantly increased frequency of the FCRL3_3 variant in women with endometriosis-related infertility over the controls (OR=1.41 [95% CI=1.08-1.84], P=0.013). However, no significant difference was found between women with endometriosis-related infertility and controls for FCRL3_4, FCRL3_5, and FCRL3_6. Regardless of the symptoms and the revised classification of the American Society of Reproductive Medicine (rASRM) stage of endometriosis, there was a significant association between FCRL3_3 variant and an increased risk of endometriosis-related infertility. Meta-analysis of previous studies combined with the present study further confirmed the association between FCRL3_3 and the risk of endometriosis-related infertility.In summary, the present study suggested that FCRL3_3 variant was associated with an increased risk of endometriosis-related infertility, regardless of symptoms, and rASRM stage of the patients. Meta-analysis of previous studies combined with the present study further confirmed our results. Further large-scale studies in the future are warranted to explore the association between FCRL3 genetic polymorphisms and endometriosis-related infertility, as well as other human diseases, in Asian and other ethnicities.
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页数:8
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