Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field

被引：36

作者：

Shams, Sara ^{[1
]}

Wahlund, Lars-Olof ^{[2
,3
]}

机构：

[1] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Med Imaging & Technol, Stockholm, Sweden

[2] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[3] Karolinska Univ Hosp, Div Clin Geriatr, Stockholm, Sweden

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期

关键词：

Alzheimer's disease; amyloid; apolipoprotein epsilon allele; biomarkers; cerebral microbleeds; cerebrospinal fluid; MRI; small vessel disease; SMALL-VESSEL DISEASE; CORTICAL SUPERFICIAL SIDEROSIS; MILD COGNITIVE IMPAIRMENT; AMYLOID ANGIOPATHY; CEREBROVASCULAR-DISEASE; CEREBROSPINAL-FLUID; P-GLYCOPROTEIN; RISK-FACTORS; INTRACEREBRAL HEMORRHAGE; IMAGING ABNORMALITIES;

D O I：

10.2217/bmm.15.101

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cerebral microbleeds (CMBs) are a marker of small vessel disease, increasingly recognized as being of importance in the Alzheimer's disease (AD) process. CMBs influence in AD, and its longitudinal impact on disease progression is however still unknown. CMBs show several associations with AD across studies, are associated with decreased cerebrospinal fluid amyloid levels and are related with the ApoE epsilon 4 allele, as well as other imaging manifestations typical for small vessel disease. CMBs, in addition to other markers of small vessel disease, are important to discover further in order to discern possible AD phenotypes.

引用

页码：9 / 18

页数：10

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