Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field

被引：36
|
作者：
Shams, Sara [1 ]
Wahlund, Lars-Olof [2 ,3 ]
机构：
[1] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Med Imaging & Technol, Stockholm, Sweden
[2] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
[3] Karolinska Univ Hosp, Div Clin Geriatr, Stockholm, Sweden
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期
关键词：
Alzheimer's disease; amyloid; apolipoprotein epsilon allele; biomarkers; cerebral microbleeds; cerebrospinal fluid; MRI; small vessel disease; SMALL-VESSEL DISEASE; CORTICAL SUPERFICIAL SIDEROSIS; MILD COGNITIVE IMPAIRMENT; AMYLOID ANGIOPATHY; CEREBROVASCULAR-DISEASE; CEREBROSPINAL-FLUID; P-GLYCOPROTEIN; RISK-FACTORS; INTRACEREBRAL HEMORRHAGE; IMAGING ABNORMALITIES;
D O I：
10.2217/bmm.15.101
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cerebral microbleeds (CMBs) are a marker of small vessel disease, increasingly recognized as being of importance in the Alzheimer's disease (AD) process. CMBs influence in AD, and its longitudinal impact on disease progression is however still unknown. CMBs show several associations with AD across studies, are associated with decreased cerebrospinal fluid amyloid levels and are related with the ApoE epsilon 4 allele, as well as other imaging manifestations typical for small vessel disease. CMBs, in addition to other markers of small vessel disease, are important to discover further in order to discern possible AD phenotypes.
引用
收藏
页码：9 / 18
页数：10
相关论文
共 50 条
  • [1] Prevalence of cerebral microbleeds in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia: A systematic review and meta-analysis
    Chin, Kai Sin
    Holper, Sarah
    Loveland, Paula
    Churilov, Leonid
    Yassi, Nawaf
    Watson, Rosie
    NEUROBIOLOGY OF AGING, 2024, 134 : 74 - 83
  • [2] Review of Cerebral Microangiopathy and Alzheimer's Disease: Relation between White Matter Hyperintensities and Microbleeds
    Hommet, C.
    Mondon, K.
    Constans, T.
    Beaufils, E.
    Desmidt, T.
    Camus, V.
    Cottier, J. P.
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2011, 32 (06) : 367 - 378
  • [3] Increased Presence of Cerebral Microbleeds Correlates With Ventricular Enlargement and Increased White Matter Hyperintensities in Alzheimer's Disease
    Kuroda, Takeshi
    Honma, Motoyasu
    Mori, Yukiko
    Futamura, Akinori
    Sugimoto, Azusa
    Yano, Satoshi
    Kinno, Ryuta
    Murakami, Hidetomo
    Ono, Kenjiro
    FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [4] Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease
    Noguchi-Shinohara, Moeko
    Komatsu, Junji
    Samuraki, Miharu
    Matsunari, Ichiro
    Ikeda, Tokuhei
    Sakai, Kenji
    Hamaguchi, Tsuyoshi
    Ono, Kenjiro
    Nakamura, Hiroyuki
    Yamada, Masahito
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 55 (03) : 905 - 913
  • [5] Matrix Metalloproteinases in Alzheimer's Disease and Concurrent Cerebral Microbleeds
    Duits, Flora H.
    Hernandez-Guillamon, Mar
    Montaner, Joan
    Goos, Jereon D. C.
    Montanola, Alex
    Wattjes, Mike P.
    Barkhof, Frederik
    Scheltens, Philip
    Teunissen, Charlotte E.
    van der Flier, Wiesje M.
    JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (03) : 711 - 720
  • [6] Disrupted White Matter Integrity and Cognitive Functions in Amyloid-β Positive Alzheimer's Disease with Concomitant Lobar Cerebral Microbleeds
    Qiao, Yanan
    Sun, Yu
    Guo, Jing
    Chen, Yaojing
    Hou, Wenjie
    Zhang, Junying
    Peng, Dantao
    JOURNAL OF ALZHEIMERS DISEASE, 2022, 85 (01) : 369 - 380
  • [7] Using Neuroimaging to Study Cerebral Amyloid Angiopathy and Its Relationship to Alzheimer's Disease
    Wheeler, Koral V.
    Irimia, Andrei
    Braskie, Meredith N.
    JOURNAL OF ALZHEIMERS DISEASE, 2024, 97 (04) : 1479 - 1502
  • [8] Cerebral Microbleeds Are Associated with Cerebral Hypoperfusion in Patients with Alzheimer's Disease
    Hatada, Yutaka
    Hashimoto, Mamoru
    Shiraishi, Shinya
    Ishikawa, Tomohisa
    Fukuhara, Ryuji
    Yuki, Seiji
    Tanaka, Hibiki
    Miyagawa, Yusuke
    Kitajima, Mika
    Uetani, Hiroyuki
    Tsunoda, Naoko
    Koyama, Asuka
    Ikeda, Manabu
    JOURNAL OF ALZHEIMERS DISEASE, 2019, 71 (01) : 273 - 280
  • [9] Cerebral small vessel disease and the risk of Alzheimer's disease: A systematic review
    Liu, Yue
    Braidy, Nady
    Poljak, Anne
    Chan, Daniel K. Y.
    Sachdev, Perminder
    AGEING RESEARCH REVIEWS, 2018, 47 : 41 - 48
  • [10] Cerebral microbleeds in early Alzheimer’s disease
    T. Poliakova
    O. Levin
    A. Arablinskiy
    E. Vasenina
    I. Zerr
    Journal of Neurology, 2016, 263 : 1961 - 1968
12345