Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status

被引：15

作者：

Chirica, Mircea ^{[1
,2
,3
]}

Le Bourhis, Lionel ^{[1
,2
]}

Lehmann-Che, Jacqueline ^{[2
,4
,5
]}

Chardiny, Victor ^{[1
,2
]}

Bouhidel, Fatiha ^{[2
,6
]}

Foulboeuf, Laure ^{[1
,2
]}

Gornet, Jean Marc ^{[2
,7
]}

Lourenco, Nelson ^{[2
,7
]}

Dulphy, Nicolas ^{[1
,2
]}

Toubert, Antoine ^{[1
,2
]}

Allez, Matthieu ^{[1
,2
,7
]}

机构：

[1] Hop St Louis, INSERM U1160, Inst Univ Hematol, Paris, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France

[3] Hop St Louis, AP HP, Dept Surg, Paris, France

[4] Hop St Louis, AP HP, Dept Biochem, Mol Oncol Unit, Paris, France

[5] Hop St Louis, CNRS INSERMU944 UMR7212, Paris, France

[6] Hop St Louis, AP HP, Dept Pathol, Paris, France

[7] Hop St Louis, AP HP, Dept Gastroenterol, Paris, France

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 08期

关键词：

Colon cancer; T cells; NKG2D; microsatellite instability; COLORECTAL-CANCER; RECEPTOR NKG2D; MUTATION; INSTABILITY;

D O I：

10.1080/2162402X.2015.1016698

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancers (CRC) develop in the face of an important immune system associated with the intestinal mucosal tissue. The immune response against the tumor has been proposed to affect the prognosis of patients undergoing treatment for CRC. In this study T cells infiltrating the tumor were compared with T cells populating the unaffected neighboring mucosal tissue and cells from the peripheral blood. We observed that T cells from the tumor harbor an activated phenotype, with engagement of the NKG2D pathway in CD8 T cells. We show that mucosal and tumor-infiltrating T cells are enriched in NKG2D CD4 T cells, which exhibit cytotoxic functions. Finally, T cell populations in the tumor were modified according to its oncogenetic status, with higher percentages of CD8 T cells isolated from patients with microsatellite instable tumor status.

引用

页数：12

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