Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia

被引：17

作者：

Danzer, Enrico ^{[1
]}

Hoffman, Casey ^{[1
]}

D'Agostino, Jo Ann ^{[1
]}

Miller, Judith S. ^{[2
]}

Waqar, Lindsay N. ^{[1
]}

Gerdes, Marsha ^{[1
]}

Bernbaum, Judy C. ^{[1
]}

Rosenthal, Hannah ^{[1
]}

Rintoul, Natalie E. ^{[1
]}

Herkert, Lisa M. ^{[1
]}

Peranteau, William H. ^{[1
]}

Flake, Alan W. ^{[1
]}

Adzick, N. Scott ^{[1
]}

Hedrick, Holly L. ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Ctr Fetal Diag & Treatment, 5th Floor Wood Ctr,3615 Civ Ctr Blvd, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Ctr Autism Res, 3535 Market St,Suite 860, Philadelphia, PA 19104 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2018年 / 48卷 / 06期

关键词：

Congenital diaphragmatic hernia; Autism spectrum disorder; Autism diagnostic observation schedule; Neurodevelopmental delay; Pulmonary hypoplasia; Pulmonary hypertension; LOW-BIRTH-WEIGHT; CHILDREN; OUTCOMES; SURVIVORS; INFANTS; PREVALENCE; SYMPTOMS; PRETERM;

D O I：

10.1007/s10803-018-3472-6

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.

引用

页码：2112 / 2121

页数：10

共 37 条

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