[1] IRCCS Mario Negri Inst Pharmacol Res, Dept Neurosci, Milan, Italy
[2] Fdn Ca Granda Osped Maggiore Policlin, Dept Anesthesiol & Intens Care, Milan, Italy
[3] Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy
[4] Univ Cambridge, Div Anaesthesia, Dept Med, Cambridge, England