Tandem Blaise-Alkenylation with Unactivated Alkynes: One-Pot Synthesis of α-Vinylated β-Enaminoesters from Nitriles

被引：36

作者：

Chun, Yu Sung ^{[2
,3
]}

Ko, Young Ok ^{[2
,3
]}

Shin, Hyunik ^{[1
]}

Lee, Sang-gi ^{[2
,3
]}

机构：

[1] LG Life Sci Ltd, R&D, Chem Dev Div, Taejon 305380, South Korea

[2] Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea

[3] Ewha Womans Univ, Nano Sci BK21, Seoul 120750, South Korea

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 15期

关键词：

CONIA-ENE REACTION; ACTIVE METHYLENE-COMPOUNDS; STEREOSELECTIVE-SYNTHESIS; 1,3-DICARBONYL COMPOUNDS; REGIOSELECTIVE-SYNTHESIS; KETOESTERS; EFFICIENT; INTERMEDIATE; CYCLIZATION; ACTIVATION;

D O I：

10.1021/ol901241s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The in situ generated Blaise reaction intermediate, a zinc bromide complex of beta-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford alpha-vinylated beta-enaminoesters in good to excellent yields.

引用

页码：3414 / 3417

页数：4

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