Innovative Solutions for the Control of Leishmaniases: Nanoscale Drug Delivery Systems

被引：12

作者：

Wagner, Victoria ^{[1
]}

Minguez-Menendez, Aida ^{[1
]}

Pena, Joan ^{[1
]}

Fernandez-Prada, Christopher ^{[1
]}

机构：

[1] Univ Montreal, Fac Med Vet, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada

来源：

CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 14期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Nanotechnology; Leishmania; drug delivery systems; liposomes; polymers; amphotericin B; antimony; miltefosine; SOLID LIPID NANOPARTICLES; NONIONIC SURFACTANT VESICLES; ENCAPSULATED AMPHOTERICIN-B; TUFTSIN-BEARING LIPOSOMES; IN-VITRO; ANTILEISHMANIAL ACTIVITY; ZINC-SULFATE; CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; SODIUM STIBOGLUCONATE;

D O I：

10.2174/1381612825666190621154552

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Leishmania are sandfly-transmitted protozoan parasites that harbour within the macrophages of a mammalian host and cause leishmaniasis, a serious zoonotic disease that threatens the lives of millions worldwide. Its numerous forms (cutaneous, mucocutaneous, and visceral) are currently treated with a sparse arsenal of drugs, specifically antimonials, amphotericin B, miltefosine, and paromomycin, for which drug resistance and clinical failure are rampant. Medicine is presently trending towards nanotechnology to aid in the successful delivery of drugs. Vehicles such as lipid-based nanocarriers, polymer-based nanoparticles, and metal ions and oxides have been previously demonstrated to improve bioavailability of drugs and decrease toxicity for the patient. 'These cutting-edge solutions can be combined with existing active molecules, as well as novel drugs or plant extracts with promising antileishmanial activity. Conclusion: This review explores the current evidence for the treatment of leishmaniases using nanoscale drug delivery systems (specifically lipid-, polymer- and metal-based systems) and encourages further development of the aforementioned nanotechnologies for treatment of Leishmania.

引用

页码：1582 / 1592

页数：11

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