Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

被引：56
|
作者：
Hu, Tao [1 ,2 ,3 ]
Li, Pei [1 ,2 ]
Luo, Zhongguang [4 ]
Chen, Xiaoyu [1 ,2 ]
Zhang, Jingyang [1 ,2 ]
Wang, Chunyao [3 ]
Chen, Ping [1 ,2 ]
Dong, Ziming [1 ,2 ]
机构：
[1] Zhengzhou Univ, Coll Basic Med Sci, Zhengzhou 450001, Henan, Peoples R China
[2] Collaborat Innovat Ctr Henan Prov Canc Chemopreve, Zhengzhou 450001, Henan, Peoples R China
[3] Zhengzhou Univ, Lab Anim Ctr, Zhengzhou 450001, Henan, Peoples R China
[4] Fudan Univ, Huashan Hosp, Dept Digest Dis, Shanghai 200040, Peoples R China
来源：
ONCOLOGY REPORTS | 2016年 / 35卷 / 01期
关键词：
chloroquine; cell cycle; DNA damage; apoptosis; liver cancer; AUTOPHAGY; APOPTOSIS; DEATH; OXALIPLATIN; ACTIVATION; PROMOTES; SURVIVAL; PATHWAY; SYSTEM; BIM;
D O I：
10.3892/or.2015.4380
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, chloroquine (CQ) has been widely used to improve the efficacy of different chemotherapy drugs to treat tumors. However, the effects of single treatment of CQ on liver cancer have not been investigated. In the present study, we examined the effects of CQ on the growth and viability of liver cancer cells in vitro and in vivo, and revealed that CQ treatment triggered G0/G1 cell cycle arrest, induced DNA damage and apoptosis in a dose- and time-dependent manner in liver cancer cells. Moreover, administration of CQ to tumor-bearing mice suppressed the tumor growth in an orthotopic xenograft model of liver cancer. These findings extend our understanding and suggest that CQ could be repositioned as a treatment option for liver cancer as a single treatment or in combination.
引用
收藏
页码：43 / 49
页数：7
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