Palladium Catalyzed Cross-Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2-b]quinazolinone

被引：19

作者：

Dabiri, Minoo ^{[1
]}

Lehi, Noushin Farajinia ^{[1
]}

Movahed, Siyavash Kazemi ^{[1
]}

Khavasi, Hamid Reza ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Fac Chem & Petr Sci, Dist 1,Daneshjou Blvd, Tehran 1983969411, Tehran Province, Iran

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 18期

关键词：

C-H activation; Palladium; Acylation; Annulation; Aldehydes; C-H; NATURAL-PRODUCTS; ACYLATION; QUINAZOLINONES; ALDEHYDES; QUINAZOLIN-4(3H)-ONES; ANILIDES; BONDS;

D O I：

10.1002/ejoc.201900417

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-butyl hydroperoxide (TBHP) as the oxidant in good yield.

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收藏

页码：2933 / 2940

页数：8

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