Microbial cancer therapeutics: A promising approach

被引：17

作者：

Diwan, Deepti ^{[1
]}

Cheng, Lei ^{[2
]}

Usmani, Zeba ^{[3
]}

Sharma, Minaxi ^{[4
]}

Holden, Nicola ^{[5
]}

Willoughby, Nicholas ^{[6
]}

Sangwan, Neelam ^{[7
]}

Baadhe, Rama Raju ^{[8
]}

Liu, Chenchen ^{[9
,10
]}

Gupta, Vijai Kumar ^{[5
,11
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO USA

[2] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Pulm, Shanghai 230032, Peoples R China

[3] Tallinn Univ Technol, Dept Chem & Biotechnol, EE-12618 Tallinn, Estonia

[4] Eternal Univ, Akal Coll Agr, Dept Food Technol, Baru Sahib 173101, Himachal Prades, India

[5] Scotlands Rural Coll SRUC, Ctr Safe & Improved Food, Kings Bldg,West Mains Rd, Edinburgh EH9 3JG, Scotland

[6] Heriot Watt Univ, Inst Biol Chem Biophys & Bioengn, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Scotland

[7] Cent Univ Haryana, Dept Biochem, Mahendergarh 123031, Haryana, India

[8] Natl Inst Technol, Dept Biotechnol, Warangal 506004, Telangana, India

[9] Fudan Univ Shanghai, Canc Ctr, Dept Gastr Surg, Shanghai 200032, Peoples R China

[10] Fudan Univ, Shanghai Med Coll, Dept Oncol, Kings Bldg,West Mains Rd, Shanghai 200032, Peoples R China

[11] Scotlands Rural Coll SRUC, Biorefining & Adv Mat Res Ctr, Kings Bldg,West Mains Rd, Edinburgh EH9 3JG, Scotland

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 86卷

基金：

中国国家自然科学基金;

关键词：

Cancer; Microbial therapy; Bacteriocins; Genetically engineered microbes; Bioactive molecules; ACUTE LYMPHOBLASTIC-LEUKEMIA; PHASE-III TRIAL; ENGINEERED SALMONELLA-TYPHIMURIUM; TUMOR-TARGETING SALMONELLA; SEDIMENT-DERIVED FUNGUS; CELL-CYCLE ARREST; NON-HDM2-MEDIATED PEPTIDE INHIBITOR; PEGYLATED ARGININE DEIMINASE; ADENOID CYSTIC CARCINOMA; METASTATIC BREAST-CANCER;

D O I：

10.1016/j.semcancer.2021.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anticancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.

引用

页码：931 / 950

页数：20

共 364 条

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