Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits

被引：139
作者：
Oosterman, Joukje M. [1 ,2 ]
van Someren, Eus J. W. [3 ,4 ,5 ,6 ,7 ]
Vogels, Raymond L. C. [8 ]
van Harten, Barbera [9 ]
Scherder, Erik J. A. [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Clin Neuropsychol, NL-1081 BT Amsterdam, Netherlands
[2] Univ Utrecht, Helmholtz Inst, Utrecht, Netherlands
[3] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
[5] Vrije Univ Amsterdam, Med Ctr, Dept Clin Neurophysiol, Amsterdam, Netherlands
[6] Vrije Univ Amsterdam, Med Ctr, Dept Psychol Med, Amsterdam, Netherlands
[7] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
[8] Med Ctr Alkmaar, Dept Neurol, Alkmaar, Netherlands
[9] Med Ctr Leeuwarden, Dept Neurol, Leeuwarden, Netherlands
来源：
JOURNAL OF SLEEP RESEARCH | 2009年 / 18卷 / 01期
关键词：
actigraphy; aging; circadian rhythm; cognitive function; sleep; SLEEP-DEPRIVATION; RETROGRADE-AMNESIA; CIRCADIAN-RHYTHMS; DECISION-MAKING; OLDER-ADULTS; DECLINE; WOMEN; ASSOCIATION; DEPRESSION; INSOMNIA;
D O I：
10.1111/j.1365-2869.2008.00704.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Aging affects both cognitive performance and the sleep-wake rhythm. The recent surge of studies that support a role of sleep for cognitive performance in healthy young adults suggests that disturbed sleep-wake rhythms may contribute to 'age-related' cognitive decline. This relationship has however not previously been extensively investigated. The present correlational study integrated a battery of standardized cognitive tests to investigate the association of mental speed, memory, and executive function with actigraphically recorded sleep-wake rhythms in 144 home-dwelling elderly participants aged 69.5 +/- 8.5 (mean +/- SD). Multiple regression analyses showed that the partial correlations of the fragmentation of the sleep-wake rhythm with each of the three cognitive domains (r = -0.16, -0.19, and -0.16 respectively) were significant. These associations were independent from main effects of age, implying that a unique relationship between the rest-activity rhythm and cognitive performance is present in elderly people.
引用
收藏
页码：129 / 135
页数：7
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