Proangiogenic penibishexahydroxanthone A from the marine-derived fungus Penicillium sp. ZZ486A

被引：6

作者：

Chen, Mengxuan ^{[1
]}

Gui, Yuhan ^{[2
]}

Zhu, Hongrui ^{[2
]}

Zhang, Zhizhen ^{[1
]}

Lin, Hou-Wen ^{[2
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan 316021, Peoples R China

[2] Shanghai Jiao Tong Univ, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes, Dept Pharm,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp. ZZ486A; Marine-derived fungus; Penibishexahydroxanthone A; Proangiogenesis; DERIVATIVES; CANCER;

D O I：

10.1016/j.tetlet.2019.04.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penibishexahydroxanthone A, a new hexahydroxanthone homodimer with a rare highly oxidized hexacyclic framework, was identified from the marine-derived Penicillium sp. ZZ486A. Its structure was determined by a combination of extensive NMR spectroscopical analyses, HRESIMS data, ECD calculation, and single crystal X-ray diffraction analysis. Penibishexahydroxanthone A showed in vivo activity in promoting angiogenesis in a dose-dependent manner by rescuing VRI-induced vascular insufficiency in zebrafish. This study is the first report of the proangiogenic activity of hexahydroxanthones. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1393 / 1396

页数：4

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