Phase Ia/Ib dose-escalation study of the anti-TIGIT antibody tiragolumab as a single agent and in combination with atezolizumab in patients with advanced solid tumors

被引：21

作者：

Bendell, Johanna C. ^{[1
]}

Bedard, Philippe ^{[2
]}

Bang, Yung-Jue ^{[3
]}

LoRusso, Patricia ^{[4
]}

Hodi, Stephen ^{[5
]}

Gordon, Michael ^{[6
]}

D'Angelo, Sandra ^{[7
]}

Desai, Jayesh ^{[8
]}

Garralda, Elena ^{[9
]}

Italiano, Antoine ^{[10
]}

Myung-Ju Ahn ^{[11
]}

Cervantes, Andres ^{[12
]}

Wainberg, Zev ^{[13
]}

Calvo, Emiliano ^{[14
]}

Gil-Martin, Marta ^{[15
]}

Martinez-Garcia, Maria ^{[16
]}

Bahleda, Rastilav ^{[17
]}

Cassier, Philippe ^{[18
]}

Delord, Jean-Pierre ^{[19
]}

Prawira, Amy ^{[20
]}

Melero, Ignacio ^{[21
]}

Emens, Leisha ^{[22
]}

Romano, Emanuela ^{[23
]}

Miller, Karen ^{[24
]}

Hsieh, Robert W. ^{[25
]}

Xue, Cloris ^{[24
]}

Morrissey, Kari ^{[24
]}

Twomey, Patrick ^{[24
]}

Gash, Kelly ^{[24
]}

Patil, Namrata S. ^{[24
]}

Grogan, Jane ^{[24
]}

Meng, Raymond ^{[24
]}

Cho, Byoung ^{[26
]}

Kim, Tae Won ^{[27
]}

机构：

[1] Sarah Cannon Res Inst, Nashville, TN USA

[2] Princess Margaret Hosp, Toronto, ON, Canada

[3] Seoul Natl Univ Hosp, Seoul, South Korea

[4] Yale Canc Ctr, New Haven, CT USA

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

[6] HonorHlth Res Inst, Scottsdale, AZ USA

[7] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[8] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[9] Hosp Univ Vall dHebron, Barcelona, Spain

[10] Inst Bergonie CLCC, Bordeaux, France

[11] Samsung Med Ctr, Seoul, South Korea

[12] Hosp Clin Univ Valencia, Valencia, Spain

[13] Univ Calif Los Angeles, Los Angeles, CA USA

[14] Hosp Univ HM Sanchinarro CIOCC, Madrid, Spain

[15] ICO Hosp, Barcelona, Spain

[16] Hosp del Mar, Barcelona, Spain

[17] Inst Gustave Roussy, Villejuif, France

[18] Ctr Leon Berard Ctr Reg Lutte Canc Rhone Alpes, Lyon, France

[19] Inst Claudius Regaud, Toulouse, France

[20] St Vincents Hosp, Darlinghurst, NSW, Australia

[21] Clin Univ Navarra, Navarra, Spain

[22] Johns Hopkins Univ, Baltimore, MD USA

[23] Inst Curie, Paris, France

[24] Genentech Inc, San Francisco, CA 94080 USA

[25] F Hoffmann La Roche, Mississauga, ON, Canada

[26] Sarah Cannon Res Inst, Seoul, South Korea

[27] Asan Med Ctr, Seoul, South Korea

来源：

CANCER RESEARCH | 2020年 / 80卷 / 16期

关键词：

D O I：

10.1158/1538-7445.AM2020-CT302

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CT302

引用

页数：3