The lipid second messenger diacylglycerol as a negative regulator of Rac signalling

被引：8

作者：

Wang, H. ^{[1
]}

Kazanietz, M. G. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

beta; 2-chimaerin; C1; domain; diacylglycerol; epidermal growth factor receptor (EGER); phorbol ester; phospholipase C gamma (PLC gamma); Rac1;

D O I：

10.1042/BST0340855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have established a novel role for the second messenger DAG (diacylglycerol), a product of PtdIns(4,5)P-2 hydrolysis by PLC (phospholipase C). in addition to its well-known function as a protein kinase C activator, DAG produced by stimulation of the epidermal growth factor receptor causes the redistribution of the Rac-GAP (GTPase-activating protein) beta 2-chimaerin to the plasma membrane, where it associates with the active form of Rac1 and promotes the inactivation of this small G-protein. This represents the first example of a Rac-GAP regulated directly by DAG in response to the activation of a tyrosine kinase receptor, and suggests a previously unappreciated role for this lipid as a negative modulator of Rac signalling.

引用

页码：855 / 857

页数：3

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