Regulatory network analysis of high expressed long non-coding RNA LINC00941 in gastric cancer

被引：38

作者：

Luo, Cong ^{[1
]}

Tao, Yang ^{[2
]}

Zhang, Yuwei ^{[2
]}

Zhu, Yinyin ^{[2
]}

Minyao, Derry Ng ^{[2
]}

Haleem, Maria ^{[2
]}

Dong, Changzheng ^{[2
]}

Zhang, Lina ^{[2
]}

Zhang, Xiaohong ^{[2
]}

Zhao, Jinshun ^{[2
]}

Liao, Qi ^{[2
]}

机构：

[1] Zhejiang Canc Hosp, Dept Abdominal Oncol, Hangzhou, Zhejiang, Peoples R China

[2] Ningbo Univ, Med Sch, Zhejiang Prov Key Lab Pathol & Physiol Technol, Dept Preventat Med, Ningbo, Zhejiang, Peoples R China

来源：

GENE | 2018年 / 662卷

基金：

中国国家自然科学基金;

关键词：

Long non-coding RNA; LINC00941; Gastric cancer; Regulatory network; CELL-PROLIFERATION; TRANSCRIPTION FACTOR; WEB SERVER; PROGNOSIS; INVASION; BINDING; EGFR; METHYLATION; METASTASIS; SUPPRESSOR;

D O I：

10.1016/j.gene.2018.04.023

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Accumulating evidence suggests that the aberrant expression of long non-coding RNAs is closely related to the carcinogenesis and progression of gastric cancer (GC), which is a type of prevalent tumor with a high incidence and mortality rate. However, it is still a challenge to find reliable biomarkers and to understand their molecular mechanisms in GC. In this study, we first confirmed that LINC00941 was up-regulated in GC tumor tissues compared with adjacent normal tissues by RT-PCR, and found that the expression level of LINC00941 was correlated with invasion depth, lymphatic metastasis, and the TNM stage of patients with GC. Furthermore, by performing enrichment analysis based on the co-expression network and regulatory network, we found that LINC00941 was associated with cancer related biological processes such as cell cycle, cell communication, cell migration, cell division, as well as processes associated with the immune system. Our results suggested that LINC00941 may be a potential novel biomarker for therapeutic or diagnostic of GC.

引用

页码：103 / 109

页数：7

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