AAV-mediated delivery of ABCA4 to the photoreceptors of Abca4-/- mice using an overlapping dual vector strategy

被引：0
作者：
McClements, Michelle E. [1 ]
Barnard, Alun R. [1 ]
Singh, Mandeep S. [2 ]
Jiang, Zhichun [3 ]
Issa, Peter Charbel [4 ]
Radu, Roxana A. [3 ]
MacLaren, Robert E. [1 ,4 ]
机构：
[1] Univ Oxford, Nuffield Dept Clin Neurosci Ophthalmol, Oxford, Oxon, England
[2] Johns Hopkins Univ, Baltimore, MD USA
[3] David Geffen Sch Med, Stein Eye Inst, Ophthalmol, Los Angeles, CA USA
[4] Oxford Eye Hosp, Oxford, England
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2017年 / 58卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
4506
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Removal of lipofuscin from the RPE of Abca4-/- mice with THPE: quantitative and toxicity studies
    Taubitz, Tatjana
    Peters, Tobias
    Poeschel, Simone
    Tschulakow, Alexander
    Rittgarn, Monika
    Schultheiss, Sigrid
    Schenke-Layland, Katja
    Burnet, Michael
    Julien, Sylvie
    Schraermeyer, Ulrich
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2015, 56 (07)
  • [22] Analysis of retinal phenotype and complement homeostasis in aged Abca4-/- Rdh8-/- mice
    Stampoulis, Dimitrios
    Moss, Stephen E.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [23] Light Damage in Abca4 and Rpe65rd12 Mice
    Wu, Li
    Ueda, Keiko
    Nagasaki, Taka
    Sparrow, Janet R.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (03) : 1910 - 1918
  • [24] Correction of Photoreceptor Function and Lipofuscin Deposits in a Model of Stargardt Disease using AAV9 Delivered ABCA4 Hybrid Dual Vectors
    Barathi, Veluchamy
    Tun, Sai Bo Bo
    SiaWey, Yeo
    Gopinath, Chitra
    Ghosh, Arkasubhra
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (08)
  • [25] Defective lysosomal calcium signaling in retinal pigmented epithelium cells from ABCA4-/- mice
    Gomez, Nestor Mas
    Lu, Wennan
    Mitchell, Claire H.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [26] Split AAV8 Mediated ABCA4 Expression for Gene Therapy of Mouse Stargardt Disease (STGD1)
    Li, Ruiting
    Jing, Qiuping
    She, Kaiqin
    Wang, Qingnan
    Jin, Xiu
    Zhao, Qinyu
    Su, Jing
    Song, Li
    Fu, Jiamei
    Wu, Xiaoyi
    Xu, Qiuxia
    Lu, Fang
    Wei, Yuquan
    Yang, Yang
    HUMAN GENE THERAPY, 2023, 34 (13-14) : 616 - 628
  • [27] All-trans retinal levels and formation of lipofuscin precursors after bleaching in rod photoreceptors from wild type and Abca4-/- mice
    Adler, Leopold
    Chen, Chunhe
    Koutalos, Yiannis
    EXPERIMENTAL EYE RESEARCH, 2017, 155 : 121 - 127
  • [28] Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo
    De Silva, S. R.
    Issa, P. Charbel
    Singh, M. S.
    Lipinski, D. M.
    Barnea-Cramer, A. O.
    Walker, N. J.
    Barnard, A. R.
    Hankins, M. W.
    MacLaren, R. E.
    GENE THERAPY, 2016, 23 (11) : 767 - 774
  • [29] Clinical manifestations of dual-gene variants involving ABCA4 in retinal dystrophies
    Lasse Wolfram
    David A. Merle
    Laura Kühlewein
    Milda Reith
    Melanie Kempf
    Krunoslav Stingl
    Tobias Haack
    Pascale Mazzola
    Karin Poths
    Nicole Weisschuh
    Bernd Wissinger
    Susanne Kohl
    Katarina Stingl
    BMC Ophthalmology, 25 (1)
  • [30] Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization
    Issa, Peter Charbel
    Barnard, Alun R.
    Herrmann, Philipp
    Washington, Ilyas
    MacLaren, Robert E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (27) : 8415 - 8420
12345