Responses to light after retinal degeneration

被引：24

作者：

Mrosovsky, N ^{[1
]}

Salmon, PA

Foster, RG

McCall, MA

机构：

[1] Univ Toronto, Dept Zool, Toronto, ON M5S 3G5, Canada

[2] Univ Toronto, Dept Psychol, Toronto, ON M5S 3G5, Canada

[3] Univ Toronto, Dept Physiol, Toronto, ON M5S 3G5, Canada

[4] Univ London Imperial Coll Sci Technol & Med, Dept Biol, London SW7 2AZ, England

[5] Univ Louisville, Dept Psychol, Louisville, KY 40202 USA

[6] Univ Louisville, Dept Ophthalmol & Visual Sci, Louisville, KY 40202 USA

来源：

VISION RESEARCH | 2000年 / 40卷 / 06期

基金：

英国医学研究理事会;

关键词：

irradiance detection; masking; mouse; retinal degeneration; rhythms; rods;

D O I：

10.1016/S0042-6989(99)00207-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transgenic rodless mice were given 1-h pulses of light of varying brightness at times of the night when they were normally active. The rodless mice showed decreases in locomotor activity during light pulses brighter than 2 lux; these decreases were significantly greater than those in wildtypes (ANOVA, P < 0.01). However, with very dim light, rodless mice showed no changes in activity, whereas wildtype mice actually increased their activity. It is suggested that irradiance detection could be enhanced by absence of image-forming vision. Enhanced inhibition of activity around twilight may be adaptive for mice in some circumstances and so help maintain genes for retinal degeneration in natural populations. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：575 / 578

页数：4

共 16 条

[1] MASKING OF CIRCADIAN ACTIVITY RHYTHMS IN CANARIES BY LIGHT AND DARK [J].