Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women

被引:38
作者
Ambrosone, Christine B. [1 ]
Zirpoli, Gary [1 ]
Hong, Chi-Chen [1 ]
Yao, Song [1 ]
Troester, Melissa A. [2 ]
Bandera, Elisa V. [3 ]
Schedin, Pepper [4 ]
Bethea, Traci N. [5 ]
Borges, Virginia [6 ]
Park, Song-Yi [7 ]
Chandra, Dhyan [1 ]
Rosenberg, Lynn [5 ]
Kolonel, Laurence N. [7 ]
Olshan, Andrew F. [2 ]
Palmer, Julie R. [5 ]
机构
[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA
[2] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC USA
[3] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA
[4] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
[5] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA
[6] Univ Colorado, Denver Sch Med, Denver, CO 80202 USA
[7] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA
来源
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2015年 / 107卷 / 09期
基金
美国国家卫生研究院;
关键词
AGE-INCIDENCE; RISK; EPIDEMIOLOGY; ASSOCIATIONS; CELLS;
D O I
10.1093/jnci/djv172
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer. Methods: In the AMBER Consortium, using harmonized data from 4426 African American women with breast cancer and 17 474 controls, we used polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for ages at menarche and first live birth (FLB), and the interval between, in relation to ER+ and ER-breast cancer. All statistical tests were two-sided. Results: Risk of ER-breast cancer was reduced with later age at menarche among both parous and nulliparous women (>= 15 vs <11 years OR = 0.62, 95% CI = 0.48 to 0.81 and OR = 0.56, 95% CI = 0.29 to 1.10, respectively), with no effect of age at FLB. For ER+ breast cancer, the inverse association was weaker among nulliparous women. While longer intervals between menarche and FLB were associated with increased risk of ER+ breast cancer in a dose-response fashion (OR for 20 year interval = 1.39, 95% CI = 1.08 to 1.79, P-trend = .003), ER-risk was only increased for intervals up to 14 years and not beyond (P-trend =.33). Conclusions: While ER-breast cancer risk was markedly reduced in women with a late age at menarche, there was not a clear pattern of increased risk with longer interval between menarche and FLB, as was observed for ER+ breast cancer. These findings indicate that etiologic pathways involving adolescence and pregnancy may differ for ER-and ER+ breast cancer.
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页数:7
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