Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A-sessiliflorus

被引：40

作者：

Jin, JL ^{[1
]}

Lee, S ^{[1
]}

Lee, YY ^{[1
]}

Kim, JM ^{[1
]}

Heo, JE ^{[1
]}

Hye, SYC ^{[1
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul, South Korea

来源：

PLANTA MEDICA | 2004年 / 70卷 / 06期

关键词：

D O I：

10.1055/s-2004-827159

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six triterpenoids, chiisanogenin, chiisanoside, ursolic acid, oleanolic acid, beta-sitosterol and daucosterol, were isolated as the platelet anti-aggregating components from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. Chiisanogenin showed about 50-fold higher potency than acetylsalicylic acid (ASA) on U46619-induced platelet aggregation (IC50: 6.21 muM) and 10-20-fold higher effects than ASA on epinephrine- and arachidonic acid (AA)-induced aggregation (IC50: 2.50 and 4.81 muM, respectively).

引用

页码：564 / 566

页数：3

共 13 条

[1]

Chandra Shekhar M., 1981, Vac News, V12, P12

[2]

HAHN DR, 1984, CHEM PHARM BULL, V32, P1244

[3] Phytochemical constituents from the fruits of Acanthopanax sessiliflorus [J].