Regulation of mTORC1 by amino acids

被引：615

作者：

Bar-Peled, Liron ^{[1
]}

Sabatini, David M. ^{[2
,3
,4
,5
,6
]}

机构：

[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[2] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[3] MIT, Dept Biol, Cambridge, MA 02142 USA

[4] Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[5] MIT, Howard Hughes Med Inst, Dept Biol, Cambridge, MA 02139 USA

[6] Broad Inst Harvard & Massachusetts Inst Technol, Cambridge, MA 02142 USA

来源：

TRENDS IN CELL BIOLOGY | 2014年 / 24卷 / 07期

基金：

美国国家卫生研究院;

关键词：

amino acid sensing; GATOR complex; Ragulator; Rag GTPases; folliculin; TUMOR-SUPPRESSOR COMPLEX; TUBEROUS SCLEROSIS GENE; TRANSFER-RNA SYNTHETASE; GTP-BINDING PROTEINS; P70; S6; KINASE; RAG GTPASES; CELL-GROWTH; CRYSTAL-STRUCTURE; EGO COMPLEX; 3-KINASE/AKT PATHWAY;

D O I：

10.1016/j.tcb.2014.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.

引用

页码：400 / 406

页数：7

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