Functional Roles of Long Non-coding RNA in Human Breast Cancer

被引：40

作者：

Ye, Ni ^{[1
]}

Wang, Bin ^{[1
]}

Quan, Zi-Fang ^{[1
]}

Cao, San-Jie ^{[1
]}

Wen, Xin-Tian ^{[1
]}

Huang, Yong ^{[1
]}

Huang, Xiao-Bo ^{[1
]}

Wu, Rui ^{[1
]}

Ma, Xiao-Ping ^{[1
]}

Yan, Qi-Gui ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Yaan, Sichuan, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 15期

关键词：

Long non - coding RNAs; biological function; breast cancer; tumorigenic mechanism; GROWTH ARREST; TUMOR-SUPPRESSOR; H19; EXPRESSION; GAS5; DIFFERENTIATION; CHROMATIN; MICRORNA; OVEREXPRESSION; PROLIFERATION;

D O I：

10.7314/APJCP.2014.15.15.5993

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.

引用

页码：5993 / 5997

页数：5

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