Functional Roles of Long Non-coding RNA in Human Breast Cancer

被引：40

作者：

Ye, Ni ^{[1
]}

Wang, Bin ^{[1
]}

Quan, Zi-Fang ^{[1
]}

Cao, San-Jie ^{[1
]}

Wen, Xin-Tian ^{[1
]}

Huang, Yong ^{[1
]}

Huang, Xiao-Bo ^{[1
]}

Wu, Rui ^{[1
]}

Ma, Xiao-Ping ^{[1
]}

Yan, Qi-Gui ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Yaan, Sichuan, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 15期

关键词：

Long non - coding RNAs; biological function; breast cancer; tumorigenic mechanism; GROWTH ARREST; TUMOR-SUPPRESSOR; H19; EXPRESSION; GAS5; DIFFERENTIATION; CHROMATIN; MICRORNA; OVEREXPRESSION; PROLIFERATION;

D O I：

10.7314/APJCP.2014.15.15.5993

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.

引用

页码：5993 / 5997

页数：5

共 55 条

[1] Keratinocyte proliferation, differentiation, and apoptosis-Differential mechanisms of regulation by curcumin, EGCG and apigenin [J].

Balasubramanian, Sivaprakasam ;

Eckert, Richard L. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 224 (03) :214-219

[2] The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis [J].

Barsyte-Lovejoy, Dalia ;

Lau, Suzanne K. ;

Boutros, Paul C. ;

Khosravi, Fereshteh ;

Jurisica, Igor ;

Andrulis, Irene L. ;

Tsao, Ming S. ;

Penn, Linda Z. .

CANCER RESEARCH, 2006, 66 (10) :5330-5337

[3] H19 mRNA-like noncoding RNA promotes breast cancer cell proliferation through positive control by E2F1 [J].

Berteaux, N ;

Lottin, V ;

Monté, D ;

Pinte, S ;

Quatannens, B ;

Coll, J ;

Hondermarck, H ;

Curgy, JJ ;

Dugimont, T ;

Adriaenssens, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (33) :29625-29636

[4] A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells [J].

Burk, Ulrike ;

Schubert, Joerg ;

Wellner, Ulrich ;

Schmalhofer, Otto ;

Vincan, Elizabeth ;

Spaderna, Simone ;

Brabletz, Thomas .

EMBO REPORTS, 2008, 9 (06) :582-589

[5] A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA [J].

Cesana, Marcella ;

Cacchiarelli, Davide ;

Legnini, Ivano ;

Santini, Tiziana ;

Sthandier, Olga ;

Chinappi, Mauro ;

Tramontano, Anna ;

Bozzoni, Irene .

CELL, 2011, 147 (02) :358-369

[6] Decoding the function of nuclear long non-coding RNAs [J].

Chen, Ling-Ling ;

Carmichael, Gordon G. .

CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (03) :357-364

[7] Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA [J].

Chen, Ling-Ling ;

Carmichael, Gordon G. .

MOLECULAR CELL, 2009, 35 (04) :467-478

[8]

Chen W, 1997, J PATHOL, V183, P345, DOI 10.1002/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO

[9]

2-8

[10] An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles [J].

Clemson, Christine M. ;

Hutchinson, John N. ;

Sara, Sergio A. ;

Ensminger, Alexander W. ;

Fox, Archa H. ;

Chess, Andrew ;

Lawrence, Jeanne B. .

MOLECULAR CELL, 2009, 33 (06) :717-726

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