Hydrogen sulfide: A new therapeutic target in vascular diseases

被引：10
|
作者：
Zhu, Cuilin [1 ,2 ]
Liu, Qing [3 ]
Li, Xin [2 ]
Wei, Ran [1 ]
Ge, Tongtong [2 ]
Zheng, Xiufen [4 ]
Li, Bingjin [2 ]
Liu, Kexiang [1 ]
Cui, Ranji [2 ]
机构：
[1] Second Hosp Jilin Univ, Dept Cardiovasc Surg, Changchun, Peoples R China
[2] Second Hosp Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China
[3] Univ Tokyo, Dept Cardiovasc Med, Tokyo, Japan
[4] Western Univ, Dept Surg, London, ON, Canada
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
中国博士后科学基金;
关键词：
hydrogen sulfide; vascular; hypertension; angiogenesis; atherosclerosis; CYSTATHIONINE GAMMA-LYASE; NITRIC-OXIDE; BLOOD-PRESSURE; HYPERPOLARIZING FACTOR; PROMOTES ANGIOGENESIS; ENDOGENOUS PRODUCTION; INDUCED RELAXATION; OXIDATIVE STRESS; BETA-SYNTHASE; H2S;
D O I：
10.3389/fendo.2022.934231
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hydrogen sulfide (H2S) is one of most important gas transmitters. H2S modulates many physiological and pathological processes such as inflammation, oxidative stress and cell apoptosis that play a critical role in vascular function. Recently, solid evidence show that H2S is closely associated to various vascular diseases. However, specific function of H2S remains unclear. Therefore, in this review we systemically summarized the role of H2S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. In addition, this review also outlined a novel therapeutic perspective comprising crosstalk between H2S and smooth muscle cell function. Therefore, this review may provide new insight inH(2)S application clinically.
引用
收藏
页数：11
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