Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems

被引：35

作者：

Li, Wei ^{[1
]}

Sun, Ya Nan ^{[1
]}

Yan, Xi Tao ^{[1
]}

Yang, Seo Young ^{[1
]}

Kim, Sohyun ^{[2
,3
,4
]}

Chae, Doobyeong ^{[2
,3
,4
]}

Hyun, Jin Won ^{[2
,3
,4
]}

Kang, Hee Kyoung ^{[2
,3
,4
]}

Koh, Young-Sang ^{[2
,3
,4
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Jeju Natl Univ, Sch Med, Cheju 690756, South Korea

[3] Jeju Natl Univ, Brain Korea Program 21, Cheju 690756, South Korea

[4] Jeju Natl Univ, Inst Med Sci, Cheju 690756, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2014年 / 37卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Desmodium caudatum; Flavonone; Xanthone; Anti-inflammatory; Antioxidant; C-GLYCOSYLFLAVONES; RESPONSES;

D O I：

10.1007/s12272-013-0241-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four flavanonols (1-4), one xanthone (5), and three flavonoid glycosides (6-8), were isolated from the leaves and stems of Desmodium caudatum. Their structures were elucidated by comparing spectroscopic data with reported values. The anti-inflammatory activity of the isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among them, compounds 1 and 2 exhibited inhibitory effects on LPS-induced IL-6, IL-12 p40, and TNF-alpha production with IC50 values ranging from 6.0 to 29.4 mu M. Compound 5 exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species scavenging activity in human HaCaT keratinocytes. These results warrant further studies of the potential anti-inflammatory and antioxidant benefits of compounds from D. caudatum.

引用

页码：721 / 727

页数：7

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