Characterization of sonic hedgehog inhibition in gastric carcinoma cells

被引：14

作者：

Bai, Ruxue ^{[1
]}

Zhao, Hongchuan ^{[1
]}

Zhang, Xiang ^{[2
]}

Du, Shiyu ^{[1
]}

机构：

[1] China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

ONCOLOGY LETTERS | 2014年 / 7卷 / 05期

关键词：

Sonic hedgehog; human gastric cancer cell; Gli; 1; CXCR4; PANCREATIC-CANCER; TGF-BETA; PATHWAY; ACTIVATION; EXPRESSION; CXCR4; OVEREXPRESSION; PROLIFERATION; INVASIVENESS; CYCLOPAMINE;

D O I：

10.3892/ol.2014.1964

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant activation of the sonic hedgehog (Shh) signaling pathway plays an important role in gastric cancer. The exact mechanisms defining how the Shh pathway promotes tumorigenesis or regulates its downstream targets remains elusive. In the present study, the effects of inhibiting the Shh signaling pathway in gastric cancer AGS cells was examined. It was identified that the Shh antagonist, cyclopamine, inhibited cancer proliferation, migration and invasion in a dose- and time-dependent manner. Additionally, it was revealed that several key targets that are activated by the Shh signaling pathway, Gli 1 and CXCR4, were downregulated at an RNA and protein level by cyclopamine. The results from the present study may be of benefit in facilitating the development of novel therapeutic strategies to treat gastric cancer in human patients.

引用

页码：1381 / 1384

页数：4

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