DABSO-Based, Three-Component, One-Pot Sulfone Synthesis

被引：193

作者：

Deeming, Alex S. ^{[1
]}

Russell, Claire J. ^{[2
]}

Hennessy, Alan J. ^{[2
]}

Willis, Michael C. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

PALLADIUM-CATALYZED AMINOSULFONYLATION; ARYL SULFONES; BIOLOGICAL-ACTIVITY; INHIBITORS; EFFICIENT; ALKYLATION; ARYLATION; OXIDATION; ALDEHYDES; HALIDES;

D O I：

10.1021/ol403122a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of Grignard reagents or organolithium reagents to the SO2-surrogate DABSO generates a diverse set of metal sulfinates, suitable for direct conversion to sulfone products. The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums.

引用

页码：150 / 153

页数：4

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