DNA binding ligands with excellent antibiotic potency against drug-resistant Gram-positive bacteria

被引：36

作者：

Bürli, RW ^{[1
]}

Ge, YG ^{[1
]}

White, S ^{[1
]}

Baird, EE ^{[1
]}

Touami, SM ^{[1
]}

Taylor, M ^{[1
]}

Kaizerman, JA ^{[1
]}

Moser, HE ^{[1
]}

机构：

[1] Genesoft Inc, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00515-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthesis of DNA binding molecules consisting of four heterocyclic carboxamide units and various substituents at both termini is described. The minor-groove binding ligands showed excellent activity against a broad range of Gram-positive bacteria; no cross-resistance to known antibacterial drugs was observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2591 / 2594

页数：4

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