Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms

被引：11

作者：

Vetchinkina, Elena ^{[1
]}

Shirokov, Alexandr ^{[1
]}

Bucharskaya, Alla ^{[2
]}

Navolokin, Nikita ^{[2
]}

Prilepskii, Artur ^{[1
]}

Burov, Andrey ^{[1
]}

Maslyakova, Galina ^{[2
]}

Nikitina, Valentina ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, 13 Prospekt Entuziastov, Saratov 410049, Russia

[2] Razumovsky State Med Univ, Russian Minist Hlth, Dept Pathol Anat, Saratov, Russia

来源：

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 2016年 / 18卷 / 11期

关键词：

antitumor activity; aqueous extracts; human laryngeal epidermoid carcinoma (H.p-2); human lung adenocarcinoma (A549); kidney tumor; medicinal Basidiomycetes; GANODERMA; POLYSACCHARIDES;

D O I：

10.1615/IntJMedMushrooms.v18.i11.10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus.dodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity. The antitumor effect of the mycelial extracts from all 3 fungal species was ascertained in vivo in rats with implanted kidney cancer. Dystrophic changes in tumor cells and tumor necrosis (up to 90%) were noted. In vitro cytotoxicity studies of the A549 human lung adenocarcinoma cell line and HEp-2 human laryngeal epidermoid carcinoma cells showed that the extracts from the G. lucidum fruiting bodies and from the L. edodes vegetative mycelium were the most effective. The animals' immune systems were activated, and the fungal extracts displayed no toxicity when administered orally.

引用

页码：955 / 964

页数：10

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