A Mild Approach for the Synthesis of Indoles from N-(2-Iodo-aryl) formamides and Phenylacetylene by a Copper(I)- and Palladium-Catalyzed Cascade Process

被引：9

作者：

Ahmed, Atiur ^{[1
]}

Ghosh, Munmun ^{[1
]}

Dhara, Shubhendu ^{[1
]}

Ray, Jayanta K. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

SYNLETT | 2014年 / 25卷 / 17期

关键词：

indole; cascade reaction; copper(I) and palladium catalyst; N-(2-iodo-aryl) formamide; hydrolysis; SOLID-PHASE SYNTHESIS; POTENT; FUNCTIONALIZATION; DERIVATIVES;

D O I：

10.1055/s-0034-1378899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot copper(I)- and palladium-catalyzed synthesis of indoles from N-(2-iodo-aryl) formamides and phenylacetylene is described. The cascade reaction comprises a Sonogashira cross-coupling, an intramolecular C-N bond formation, and hydrolysis of the intermediate indole-1-carbaldehyde promoted by the same catalyst and base systems.

引用

页码：2455 / 2458

页数：4

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