A novel approach to the synthesis of 5-trifluoromethyl-3-substituted pyrazoles

被引：21

作者：

Krishnaiah, A ^{[1
]}

Narsaiah, B ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 2, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2002年 / 115卷 / 01期

关键词：

2(1H) pyridones; bis-nucleophiles; pyrazoles;

D O I：

10.1016/S0022-1139(01)00501-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The 3-cyano-4-trifluoromethyl-6-phenyl or substituted phenyl 2(1H) pyridones (1) on reaction with hydrazine hydrate, gave exclusively in 5-trifluoromethyl-3-substituted pyrazoles (3) through a novel method. A possible mechanistic pathway for change in the site of nucleophilic attack due to the CF3 group in 2(1H) pyridones is described. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：9 / 11

页数：3

共 32 条

[1] ALEKSEEV VV, 1995, ZH ORG KHIM, V937, P31
[2] Haloacetylated enol ethers 10.: Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide.: Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides
Bonacorso, HG
Wastowski, AD
Zanatta, N
Martins, MAP
Naue, JA
[J]. JOURNAL OF FLUORINE CHEMISTRY, 1998, 92 (01) : 23 - 26
[3] FLUORINE-CONTAINING INTERMEDIATES FOR PESTICIDES
BRADEN, RPJ
KLAUKE, E
[J]. PESTICIDE SCIENCE, 1986, 17 (04): : 418 - 429
[4] Buntain I. G., 1988, Patent No. [0295117A1, 0295117]
[5] Filler R., 1982, BIOMEDICAL ASPECTS F
[6] SOME NEW APPROACHES TO MODIFYING AROMATIC AND HETEROAROMATIC-COMPOUNDS BY MEANS OF FLUORINE-CONTAINING SUBSTITUENTS
FOKIN, AV
KOLOMIYETS, AF
[J]. JOURNAL OF FLUORINE CHEMISTRY, 1988, 40 (2-3) : 247 - 259
[7] Guan HP, 1997, SYNTHESIS-STUTTGART, P1489
[8] REGIOSELECTIVE SYNTHESIS OF 1-METHYL-3-HYDROXY-5-PERFLUOROALKYLPYRAZOLES BY THE ADDITION OF METHYLHYDRAZINE TO PERFLUOROALKYLACETYLENIC ESTERS
HAMPER, BC
[J]. JOURNAL OF FLUORINE CHEMISTRY, 1990, 48 (01) : 123 - 131
[9] HATANAKA M, 1990, Patent No. 0253775
[10] FLUORINATED PYRIMIDINES, A NEW CLASS OF TUMOUR-INHIBITORY COMPOUNDS
HEIDELBERGER, C
CHAUDHURI, NK
DANNEBERG, P
MOOREN, D
GRIESBACH, L
DUSCHINSKY, R
SCHNITZER, RJ
PLEVEN, E
SCHEINER, J
[J]. NATURE, 1957, 179 (4561) : 663 - 666

← 1 2 3 4 →