Intralesional Collagenase Clostridium histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis

被引:38
作者
Hellstrom, Wayne J. G. [1 ]
Nguyen, Hoang Minh Tue [1 ]
Alzweri, Laith [1 ]
Chung, Amanda [2 ]
Virasoro, Ramon [2 ]
Tapscott, Ashley [5 ]
Ziegelmann, Matthew [3 ]
Trost, Landon [3 ]
Gelbard, Martin [4 ]
机构
[1] Tulane Univ, Sch Med, Dept Urol, 1430 Tulane Ave,86-42, New Orleans, LA 70112 USA
[2] Eastern Virginia Med Sch, Norfolk, VA 23501 USA
[3] Mayo Clin, Rochester, MN USA
[4] Univ Calif Los Angeles, Los Angeles, CA USA
[5] Carolina Urol Partners, Huntersville, NC USA
关键词
penile induration; microbial collagenase; Clostridium histolyticum; complications; treatment outcome; SAFETY; EFFICACY;
D O I
10.1097/JU.0000000000000032
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose:In a multi-institutional setting we studied the efficacy and safety outcomes at multiple high volume centers where collagenase Clostridium histolyticum is used to treat Peyronie's disease.Materials and Methods:We collected retrospective data on consecutive patients with Peyronie's disease who underwent treatment with collagenase C. histolyticum between April 2014 and March 2018 at a total of 5 institutions. Included in the study were 918 patients. Main outcomes of interest included the change in curvature after receiving collagenase C. histolyticum therapy and the frequency of serious treatment related adverse events. The 2-tailed paired Student t-test was used to compare continuous variables. Univariate and multivariate regression analyses were performed to assess predictors of the success of collagenase C. histolyticum therapy to improve curvature.Results:In the cohort of 918 patients curvature improved from a mean of 48.2 degrees before treatment to 32.9 degrees after treatment, a 30.1% improvement from baseline (p <0.0001). Of the men 68.7% had a 20% or greater improvement in curvature. In the 502 patients who completed 4 or more cycles curvature improved from a mean of 49.7 degrees before to 32.7 degrees after treatment, a 33% improvement from baseline (p <0.0001). Of these men 74.4% experienced a 20% or greater improvement in curvature. A complication of treatment developed in 9% of patients. The number of cycles of collagenase C. histolyticum received was predictive of curvature improvement (p <0.0001).Conclusions:This large multi-institutional analysis confirms the safety and efficacy of collagenase C. histolyticum therapy in men with Peyronie's disease. Intralesional collagenase C. histolyticum for Peyronie's disease according to the IMPRESS (Investigation of Maximal Peyronie's Reduction Efficacy and Safety Studies) trial protocol produced an improvement in penile curvature in men with Peyronie's disease with a low rate of complications.
引用
收藏
页码:777 / 782
页数:6
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