Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China

被引：16

作者：

Ishikawa, Hitoshi

Tian, Ying

Piao, Fengyuan

Duan, Zhiwen

Zhang, Yumin

Ma, Mingyue

Li, Haishan

Yamamoto, Hidetaka

Matsumoto, Yutaka

Sakai, Shigekatsu

Cui, Jinshan

Yamauchi, Toru

Yokoyama, Kazuhito

机构：

[1] Yamagata Univ, Grad Sch Med, Dept Publ Hlth, Yamagata 9909585, Japan

[2] Mie Univ, Grad Sch Med, Dept Publ Hlth & Occupat Med, Tsu, Mie 5148507, Japan

[3] Mie Univ, Grad Sch Med, Tsu, Mie 5148507, Japan

[4] Hokkaido Res Inst Environm Sci, Kita Ku, Sapporo, Hokkaido 0600819, Japan

[5] Shenyang Med Coll, Fac Prevent Med, Dept Toxicol, Shenyang, Peoples R China

[6] Shanghai Med Univ 2, Sch Publ Hlth, Shanghai 200025, Peoples R China

来源：

CANCER LETTERS | 2006年 / 240卷 / 01期

关键词：

micronuclei; lymphocytes; polycyclic aromatic hydrocarbon; DNA polymorphism; air pollution;

D O I：

10.1016/j.canlet.2005.08.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Air pollution has been suggested to cause genetic damage from investigations of many biological markers that measure cytogenetic damage in humans. Here, we evaluated the genotoxic effects of ambient air pollution by investigating the extent of cytogenetic damage in human blood lymphocytes from rural and industrial female residents of Shenyang city, China, using micronuclei assays and polymorphic analyses of metabolic enzyme and DNA repair genes. After adjustment for potential confounding factors including DNA polymorphisms, industrial female residents were found to have a higher micronuclei frequency. These results provide evidence that micronuclei assays are a sensitive indicator to air pollution-induced genotoxic effects in humans. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：29 / 35

页数：7

共 48 条

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