A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

被引：62

作者：

Reindl, Wolfgang ^{[2
]}

Yuan, Juping ^{[1
]}

Kraemer, Andrea ^{[1
]}

Strebhardt, Klaus ^{[1
]}

Berg, Thorsten ^{[2
]}

机构：

[1] Univ Frankfurt, Sch Med, Dept Gynecol & Obstet, D-60596 Frankfurt, Germany

[2] Max Planck Inst Biochem, Dept Mol Biol, CIPSM, D-82152 Martinsried, Germany

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 07期

关键词：

enzymes; inhibitors; mitosis; polo-like kinases; protein-protein interactions; SMALL-MOLECULE INHIBITOR; PLK1; POLO-LIKE-KINASE-1; LOCALIZATION; APOPTOSIS; PROLIFERATION; CYTOKINESIS; DISCOVERY; DIVISION; BI-2536;

D O I：

10.1002/cbic.200900059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1145 / 1148

页数：4

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