Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)

被引：17

作者：

Cockeran, Riana ^{[1
,2
]}

Herbert, Jenny A. ^{[3
,4
]}

Mitchell, Timothy J. ^{[3
,4
]}

Dix-Peek, Therese ^{[5
,6
,7
]}

Dickens, Caroline ^{[5
,6
,7
]}

Anderson, Ronald ^{[1
]}

Feldman, Charles ^{[5
,6
,7
]}

机构：

[1] Univ Pretoria, Fac Hlth Sci, Dept Immunol, Med Res Council Unit Inflammat & Immun, ZA-0001 Pretoria, South Africa

[2] Tshwane Acad Div, Natl Hlth Lab Serv, ZA-2192 Johannesburg, South Africa

[3] Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

[4] Univ Birmingham, Sch Immun & Infect, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England

[5] Univ Witwatersrand, Fac Hlth Sci, Dept Internal Med, Div Haematol, ZA-2050 Johannesburg, South Africa

[6] Univ Witwatersrand, Fac Hlth Sci, Dept Internal Med, Div Pulmonol, ZA-2050 Johannesburg, South Africa

[7] Charlotte Maxeke Johannesburg Acad Hosp, ZA-2050 Johannesburg, South Africa

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

BIOFILM FORMATION; VIRULENCE;

D O I：

10.1155/2014/976347

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 mu g/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

引用

页数：4

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