Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance

被引：64
作者：
D'Souza, Kenneth [1 ]
Paramel, Geena V. [1 ]
Kienesberger, Petra C. [1 ]
机构：
[1] Dalhousie Univ, Fac Med, Dept Biochem & Mol Biol, Dalhousie Med New Brunswick, St John, NB E2L 4L5, Canada
来源：
NUTRIENTS | 2018年 / 10卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
lysophosphatidic acid; lysophospholipids; autotaxin; obesity; insulin resistance; adipocytes; cardiovascular disease; diet; BROWN ADIPOSE-TISSUE; DIET-INDUCED OBESITY; PROTEIN-COUPLED RECEPTOR; NECROSIS-FACTOR-ALPHA; AUTOTAXIN EXPRESSION; GLUCOSE-HOMEOSTASIS; IN-VITRO; PREADIPOCYTE PROLIFERATION; ADIPOCYTE DIFFERENTIATION; CARDIOVASCULAR-DISEASE;
D O I：
10.3390/nu10040399
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX). Alterations in LPA signaling, in conjunction with changes in autotaxin (ATX) expression and activity, have been implicated in metabolic and inflammatory disorders including obesity, insulin resistance, and cardiovascular disease. This review summarizes our current understanding of the sources and metabolism of LPA with focus on the influence of diet on circulating LPA. Furthermore, we explore how the ATX-LPA pathway impacts obesity and obesity-associated disorders, including impaired glucose homeostasis, insulin resistance, and cardiovascular disease.
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页数：20
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