Burkitt Lymphoma and Other 8 High-Grade B-Cell Lymphomas with or without MYC, BCL2, and/or BCL6 Rearrangements

被引：13

作者：

Alsharif, Rami ^{[1
]}

Dunleavy, Kieron ^{[1
]}

机构：

[1] George Washington Univ, Canc Ctr, Dept Hematol & Oncol, 2150 Penn Ave, Washington, DC 20037 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 04期

关键词：

Burkitt lymphoma; Risk-adapted; High-grade B-cell lymphoma; MYC with BCL2 and/or BCL6; DOSE-ADJUSTED EPOCH; MODIFIED CODOX-M/IVAC; ADULT BURKITT; PROGNOSTIC-FACTORS; CLINICAL-FEATURES; POOR-PROGNOSIS; RITUXIMAB; CHEMOTHERAPY; GENE; PATHOGENESIS;

D O I：

10.1016/j.hoc.2019.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Burkitt lymphoma (BL) is highly aggressive and requires very intensive chemotherapy approaches for successful treatment. Although "standard" approaches are tolerated in young patients, this is not the case in older adults, and new approaches that lower toxicity but maintain high curability are needed and are currently in development. Recently, high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements have been categorized separately from diffuse large B-cell lymphoma or BL. These have poor outcomes and many exciting novel approaches are being tested in an attempt to augment curability. These diseases harbor many interesting targets for rational small molecule inhibition in future trials.

引用

收藏

页码：587 / +

页数：11

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