Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

被引：8

作者：

Mei, Rongqing ^{[1
]}

Huang, Guolei ^{[1
]}

Wang, Bin ^{[1
]}

Bai, Meng ^{[1
]}

Luo, Youping ^{[1
]}

Chen, Guangying ^{[1
]}

Zheng, Caijuan ^{[1
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem, Key Lab Trop Med Plant Chem Hainan Prov,Minist Ed, Haikou 571158, Hainan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Penicillium citrinum; isocoumarin; antibacterial activity; alpha-glucosidase inhibitory activity;

D O I：

10.6023/cjoc201812008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against alpha-glucosidase with the IC50 values of 18.37 and 25.86 mu g/mL, respectively.

引用

页码：1479 / 1482

页数：4

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