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Glycosaminoglycans from a Sea Snake (Lapemis curtus): Extraction, Structural Characterization and Antioxidant Activity
被引:21
作者:

Bai, Mingyue
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机构:
Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China
Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China

Han, Wenwei
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机构:
Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China
Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China

Zhao, Xia
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h-index: 0
机构:
Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China
Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China

Wang, Qingchi
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机构:
Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China

Gao, Yanyun
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h-index: 0
机构:
Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China

Deng, Shiming
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机构:
Hainan Univ, Ocean Coll, Haikou 570228, Hainan, Peoples R China Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China
机构:
[1] Ocean Univ Qingdao, Minist Educ, Shandong Prov Key Lab Glycosci & Glycoengn, Key Lab Marine Drugs,Sch Med & Pharm, Qingdao 266003, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
[3] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China
[4] Hainan Univ, Ocean Coll, Haikou 570228, Hainan, Peoples R China
关键词:
Lapemis curtus;
glycosaminoglycans;
chondroitin sulfate;
dermatan sulfate;
structural characterization;
antioxidant activities;
CHONDROITIN SULFATES;
ACID;
OLIGOSACCHARIDES;
POLYSACCHARIDES;
ANTICOAGULANT;
OIL;
D O I:
10.3390/md16050170
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Sea snakes have wide application prospects in medicine, health food and other fields. Several novel polysaccharides were successfully obtained from the skin and the meat of a sea snake (Lapemis curtus). The structures of polysaccharides LSP3 and LMP3, which were extracted and purified from Lapemis curtus, were determined to be new and highly heterogenic glycosaminoglycans (GAGs) by means of FT-IR, ESI-MS/MS and NMR. LSP3 is a hybrid dermatan sulfate (DS) and composed of 48% 4-sulfated disaccharides (Di4S), 42% 6-sulfated disaccharides (Di6S) and 5% disulfated disaccharides (Di2,6S), while LMP3 is a hybrid chondroitin sulfate (CS) and composed of 70% Di4S, 20% Di6S, and 8% Di2,6S. More importantly, LSP3 and LMP3 showed a strong scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, iron (Fe2+) chelating activity and total antioxidant capacity in vitro, especially LSP3, with high contents of uronic acid and sulfate, which possessed a higher scavenging ability of DPPH radicals than other fractions. These data suggested that the sea snake polysaccharides could be promising candidates for natural antioxidant ingredients.
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共 27 条
[21]
Glycosaminoglycans from marine sources as therapeutic agents
[J].
Valcarcel, Jesus
;
Novoa-Carballal, Ramon
;
Perez-Martin, Ricardo I.
;
Reis, Rui L.
;
Antonio Vazquez, Jose
.
BIOTECHNOLOGY ADVANCES,
2017, 35 (06)
:711-725

Valcarcel, Jesus
论文数: 0 引用数: 0
h-index: 0
机构:
IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain
IIM CSIC, Marine Res Inst, Grp Food Biochem, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain

Novoa-Carballal, Ramon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minho, Headquarters European Inst Excellence Tissue Engn, Res Grp Biomat Biodegradables & Biomimet 3Bs, Ave Pk, P-4805017 Barco, Guimaraes, Portugal
Govt Associate Lab, ICVS PT 3Bs, Braga, Guimaraes, Portugal IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain

Perez-Martin, Ricardo I.
论文数: 0 引用数: 0
h-index: 0
机构:
IIM CSIC, Marine Res Inst, Grp Food Biochem, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain

Reis, Rui L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minho, Headquarters European Inst Excellence Tissue Engn, Res Grp Biomat Biodegradables & Biomimet 3Bs, Ave Pk, P-4805017 Barco, Guimaraes, Portugal
Govt Associate Lab, ICVS PT 3Bs, Braga, Guimaraes, Portugal IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain

Antonio Vazquez, Jose
论文数: 0 引用数: 0
h-index: 0
机构:
IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain IIM CSIC, Marine Res Inst, Grp Recycling & Valorisat Waste Mat REVAL, R Eduardo Cabello 6, Vigo 36208, Pontevedra, Spain
[22]
Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins
[J].
Xu, Yongmei
;
Masuko, Sayaka
;
Takieddin, Majde
;
Xu, Haoming
;
Liu, Renpeng
;
Jing, Juliana
;
Mousa, Shaker A.
;
Linhardt, Robert J.
;
Liu, Jian
.
SCIENCE,
2011, 334 (6055)
:498-501

Xu, Yongmei
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Masuko, Sayaka
论文数: 0 引用数: 0
h-index: 0
机构:
Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Takieddin, Majde
论文数: 0 引用数: 0
h-index: 0
机构:
Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Albany, NY 12208 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Xu, Haoming
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Liu, Renpeng
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Jing, Juliana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Mousa, Shaker A.
论文数: 0 引用数: 0
h-index: 0
机构:
Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Albany, NY 12208 USA
King Saud Univ, Coll Med, Riyadh 11461, Saudi Arabia Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Linhardt, Robert J.
论文数: 0 引用数: 0
h-index: 0
机构:
Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA

Liu, Jian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA
[23]
Study on quality control of sulfated polysaccharide drug, propylene glycol alginate sodium sulfate (PSS)
[J].
Xue, Yi-Ting
;
Ren, Li
;
Li, Shuang
;
Wang, Lin-lin
;
He, Xiao-Xi
;
Zhao, Xia
;
Yu, Guang-li
;
Guan, Hua-Shi
;
Li, Chun-Xia
.
CARBOHYDRATE POLYMERS,
2016, 144
:330-337

Xue, Yi-Ting
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Ren, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Li, Shuang
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Wang, Lin-lin
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

He, Xiao-Xi
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Zhao, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Yu, Guang-li
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Guan, Hua-Shi
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

Li, Chun-Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Shandong, Peoples R China Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China
[24]
Structural characterization of chondroitin/dermatan sulfate oligosaccharides from bovine aorta by capillary electrophoresis and electrospray ionization quadrupole time-of-flight tandem mass spectrometry
[J].
Zamfir, A
;
Seidler, DG
;
Kresse, H
;
Peter-Katalinic, J
.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY,
2002, 16 (21)
:2015-2024

Zamfir, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munster, Inst Med Phys & Biophys, Biomed Anal Dept, D-48149 Munster, Germany

Seidler, DG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munster, Inst Med Phys & Biophys, Biomed Anal Dept, D-48149 Munster, Germany

Kresse, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munster, Inst Med Phys & Biophys, Biomed Anal Dept, D-48149 Munster, Germany

Peter-Katalinic, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munster, Inst Med Phys & Biophys, Biomed Anal Dept, D-48149 Munster, Germany
[25]
Ultrasound extraction of polysaccharides from mulberry leaves and their effect on enhancing antioxidant activity
[J].
Zhang, Dong-Yang
;
Wan, Yi
;
Xu, Jian-Yi
;
Wu, Guo-Hua
;
Li, Long
;
Yao, Xiao-Hui
.
CARBOHYDRATE POLYMERS,
2016, 137
:473-479

Zhang, Dong-Yang
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China

Wan, Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China

Xu, Jian-Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China

Wu, Guo-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China

Li, Long
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China

Yao, Xiao-Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China Jiangsu Univ Sci & Technol, Coll Biotechonl & Sericultural Res Inst, Zhenjiang 212018, Peoples R China
[26]
Preparation of low-molecular-weight polyguluronate sulfate and its anticoagulant and anti-inflammatory activities
[J].
Zhao, Xia
;
Yu, Guangli
;
Guan, Huashi
;
Yue, Nan
;
Zhang, Zhenqing
;
Li, Haihua
.
CARBOHYDRATE POLYMERS,
2007, 69 (02)
:272-279

Zhao, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

Yu, Guangli
论文数: 0 引用数: 0
h-index: 0
机构: Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

Guan, Huashi
论文数: 0 引用数: 0
h-index: 0
机构: Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

Yue, Nan
论文数: 0 引用数: 0
h-index: 0
机构: Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

Zhang, Zhenqing
论文数: 0 引用数: 0
h-index: 0
机构: Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China

Li, Haihua
论文数: 0 引用数: 0
h-index: 0
机构: Ocean Univ China, Inst Marine Drug & Food, Qingdao 266003, Peoples R China
[27]
Acidolysis-based component mapping of glycosaminoglycans by reversed-phase high-performance liquid chromatography with off-line electrospray ionization-tandem mass spectrometry: Evidence and tags to distinguish different glycosaminoglycans
[J].
Zhu, He
;
Chen, Xuan
;
Zhang, Xiao
;
Liu, Lili
;
Cong, Dapeng
;
Zhao, Xia
;
Yu, Guangli
.
ANALYTICAL BIOCHEMISTRY,
2014, 465
:63-69

Zhu, He
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Chen, Xuan
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Zhang, Xiao
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Liu, Lili
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Cong, Dapeng
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Zhao, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China
Ocean Univ China, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

Yu, Guangli
论文数: 0 引用数: 0
h-index: 0
机构:
Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China
Ocean Univ China, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China Ocean Univ China, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China