Clinical applications of angiogenic growth factors and their inhibitors

被引：847
作者：
Ferrara, N
Alitalo, K
机构：
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
[2] Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland
来源：
NATURE MEDICINE | 1999年 / 5卷 / 12期
关键词：
D O I：
10.1038/70928
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.
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收藏
页码：1359 / 1364
页数：6
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