Too much of a good thing: Management of BCG vaccine overdose

被引：12
作者：
Ritz, Nicole [1 ,2 ,3 ]
Tebruegge, Marc [1 ,2 ,3 ]
Streeton, Jonathan [4 ]
Curtis, Nigel [1 ,2 ,3 ]
机构：
[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia
[2] Royal Childrens Hosp Melbourne, Dept Gen Med, Infect Dis Unit, Melbourne, Vic, Australia
[3] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[4] St Vincents & Mercy Private Hosp, Melbourne, Australia
来源：
VACCINE | 2009年 / 27卷 / 41期
关键词：
BCG; Overdose; Vaccine; Immunisation; Tuberculosis; Medical error; BACILLE CALMETTE-GUERIN; LYMPHADENITIS; TUBERCULOSIS;
D O I：
10.1016/j.vaccine.2009.07.043
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12 h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5562 / 5564
页数：3
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