Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice

被引：45

作者：

Fassan, Matteo ^{[1
]}

Scarpa, Aldo ^{[2
,3
]}

Remo, Andrea ^{[4
]}

De Maglio, Giovanna ^{[5
]}

Troncone, Giancarlo ^{[6
]}

Marchetti, Antonio ^{[7
]}

Doglioni, Claudio ^{[8
,9
]}

Ingravallo, Giuseppe ^{[10
]}

Perrone, Giuseppe ^{[11
]}

Parente, Paola ^{[12
]}

Luchini, Claudio ^{[3
]}

Mastracci, Luca ^{[13
,14
]}

机构：

[1] Univ Padua, Dept Med DIMED, Surg Pathol Unit, Padua, Italy

[2] Univ Verona, ARC NET Res Ctr, Verona, Italy

[3] Univ & Hosp Trust Verona, Dept Diagnost & Publ Hlth, Sect Pathol, Piazzale LA Scuro 10, I-37134 Verona, VR, Italy

[4] ULSS9 Scaligera, Pathol Unit, Serv Dept, Verona, Italy

[5] Univ Hosp Udine, Dept Pathol, Udine, Italy

[6] Federico II Univ Med Sch Naples, Dept Publ Hlth, Naples, Italy

[7] Univ G dAnnunzio, Ctr Predict Mol Med, Ctr Excellence Aging & Translat Med, Chieti, Italy

[8] Vita & Salute Univ, Milan, Italy

[9] IRCCS, Pancreas Translat & Clin Res Ctr, Pathol Unit, San Raffaele Sci Inst, Milan, Italy

[10] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Sect Pathol Anat, Bari, Italy

[11] Campus Biomed Univ, Dept Pathol, Rome, Italy

[12] Fdn IRCCS Osped Casa Sollievo Sofferenza, Pathol Unit, San Giovanni Rotondo, FG, Italy

[13] San Martino IRCCS Hosp, Anat Pathol, Genoa, Italy

[14] Univ Genoa, Dept Surg Sci & Integrated Diagnost DISC, Anat Pathol, Genoa, Italy

来源：

PATHOLOGICA | 2020年 / 112卷 / 03期

关键词：

prognostic markers; predictive markers; targeted therapy; molecular pathology; immunohistochemistry; METASTATIC COLORECTAL-CANCER; MISMATCH REPAIR DEFICIENCY; EPSTEIN-BARR-VIRUS; OF-AMERICAN-PATHOLOGISTS; HER2 SCORING SYSTEM; MICROSATELLITE INSTABILITY; GASTRIC-CANCER; LYNCH-SYNDROME; BRAF MUTATION; MOLECULAR CHARACTERIZATION;

D O I：

10.32074/1591-951X-158

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The pathologist emerged in the personalized medicine era as a central actor in the definition of the most adequate diagnostic and therapeutic algorithms. In the last decade, gastrointestinal oncology has seen a significantly increased clinical request for the integration of novel prognostic and predictive biomarkers in histopathological reports. This request couples with the significant contraction of invasive sampling of the disease, thus conferring to the pathologist the role of governor for both proper pathologic characterization and customized processing of the biospecimens. This overview will focus on the most commonly adopted immunohistochemical and molecular biomarkers in the routine clinical characterization of gastrointestinal neoplasms referring to the most recent published recommendations, guidelines and expert opinions.

引用

页码：248 / 259

页数：12

共 112 条

[61] CK7 and consensus molecular subtypes as major prognosticators in V600EBRAF mutated metastatic colorectal cancer [J].

Loupakis, Fotios ;

Biason, Paola ;

Prete, Alessandra Anna ;

Cremolini, Chiara ;

Pietrantonio, Filippo ;

Pella, Nicoletta ;

Dell'Aquila, Emanuela ;

Sperti, Elisa ;

Zichi, Clizia ;

Intini, Rossana ;

Dadduzio, Vincenzo ;

Schirripa, Marta ;

Bergamo, Francesca ;

Antoniotti, Carlotta ;

Morano, Federica ;

Cortiula, Francesco ;

De Maglio, Giovanna ;

Rimassa, Lorenza ;

Smiroldo, Valeria ;

Calvetti, Lorenzo ;

Aprile, Giuseppe ;

Salvatore, Lisa ;

Santini, Daniele ;

Munari, Giada ;

Salmaso, Roberta ;

Guzzardo, Vincenza ;

Mescoli, Claudia ;

Lonardi, Sara ;

Rugge, Massimo ;

Zagonel, Vittorina ;

Di Maio, Massimo ;

Fassan, Matteo .

BRITISH JOURNAL OF CANCER, 2019, 121 (07) :593-599

[62] A validated prognostic classifier for V600EBRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study [J].

Loupakis, Fotios ;

Intini, Rossana ;

Cremolini, Chiara ;

Orlandi, Armando ;

Sartore-Bianchi, Andrea ;

Pietrantonio, Filippo ;

Pella, Nicoletta ;

Spallanzani, Andrea ;

Dell'Aquila, Emanuela ;

Scartozzi, Mario ;

De Luca, Emmanuele ;

Rimassa, Lorenza ;

Formica, Vincenzo ;

Leone, Francesco ;

Calvetti, Lorenzo ;

Aprile, Giuseppe ;

Antonuzzo, Lorenzo ;

Urbano, Federica ;

Prenen, Hans ;

Negri, Francesca ;

Di Donato, Samantha ;

Buonandi, Pasquale ;

Tomasello, Gianluca ;

Avallone, Antonio ;

Zustovich, Fable ;

Moretto, Roberto ;

Antoniotti, Carlotta ;

Salvatore, Lisa ;

Calegari, Maria Alessandra ;

Siena, Salvatore ;

Morano, Federica ;

Ongaro, Elena ;

Cascinu, Stefano ;

Santini, Daniele ;

Ziranu, Pina ;

Schirripa, Marta ;

Buggin, Federica ;

Prete, Alessandra Anna ;

Depetris, Ilaria ;

Biason, Paola ;

Lonardi, Sara ;

Zagonel, Vittorina ;

Fassan, Matteo ;

Di Maio, Massimo .

EUROPEAN JOURNAL OF CANCER, 2019, 118 :121-130

[63] Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study [J].

Lowery, Maeve A. ;

Burris, Howard A., III ;

Janku, Filip ;

Shroff, Rachna T. ;

Cleary, James M. ;

Azad, Nilofer S. ;

Goyal, Lipika ;

Maher, Elizabeth A. ;

Gore, Lia ;

Hollebecque, Antoine ;

Beeram, Muralidhar ;

Trent, Jonathan C. ;

Jiang, Liewen ;

Fan, Bin ;

Aguado-Fraile, Elia ;

Choe, Sung ;

Bin Wu ;

Gliser, Camelia ;

Agresta, Samuel, V ;

Pandya, Shuchi S. ;

Zhu, Andrew X. ;

Abou-Alfa, Ghassan K. .

LANCET GASTROENTEROLOGY & HEPATOLOGY, 2019, 4 (09) :711-720

[64] ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach [J].

Luchini, C. ;

Bibeau, F. ;

Ligtenberg, M. J. L. ;

Singh, N. ;

Nottegar, A. ;

Bosse, T. ;

Miller, R. ;

Riaz, N. ;

Douillard, J. -Y. ;

Andre, F. ;

Scarpa, A. .

ANNALS OF ONCOLOGY, 2019, 30 (08) :1232-1243

[65] Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications [J].

Luchini, Claudio ;

Brosens, Lodewijk A. A. ;

Wood, Laura D. ;

Chatterjee, Deyali ;

Shin, Jae Il ;

Sciammarella, Concetta ;

Fiadone, Giulia ;

Malleo, Giuseppe ;

Salvia, Roberto ;

Kryklyva, Valentyna ;

Piredda, Maria L. ;

Cheng, Liang ;

Lawlor, Rita T. ;

Adsay, Volkan ;

Scarpa, Aldo .

GUT, 2021, 70 (01) :148-156

[66] PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: A expression patterns and clinical implications [J].

Luchini, Claudio ;

Cros, Jerome ;

Pea, Antonio ;

Pilati, Camilla ;

Veronese, Nicola ;

Rusev, Borislav ;

Capelli, Paola ;

Mafficini, Andrea ;

Nottegar, Alessia ;

Brosens, Lodewijk A. A. ;

Noe, Michael ;

Offerhaus, G. Johan A. ;

Chianchiano, Peter ;

Riva, Giulio ;

Piccoli, Paola ;

Parolini, Claudia ;

Malleo, Giuseppe ;

Lawlor, Rita T. ;

Corbo, Vincenzo ;

Sperandio, Nicola ;

Barbareschi, Mattia ;

Fassan, Matteo ;

Cheng, Liang ;

Wood, Laura D. ;

Scarpa, Aldo .

HUMAN PATHOLOGY, 2018, 81 :157-165

[67]

Luchini Claudio, 2016, Surg Pathol Clin, V9, P547, DOI 10.1016/j.path.2016.05.003

[68] The therapeutic significance of mutational signatures from DNA repair deficiency in cancer [J].

Ma, Jennifer ;

Setton, Jeremy ;

Lee, Nancy Y. ;

Riaz, Nadeem ;

Powell, Simon N. .

NATURE COMMUNICATIONS, 2018, 9

[69] Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization [J].

Mathiak, Micaela ;

Warneke, Viktoria S. ;

Behrens, Hans-Michael ;

Haag, Jochen ;

Boeger, Christine ;

Krueger, Sandra ;

Roecken, Christoph .

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2017, 25 (01) :12-24

[70] Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma [J].

Mazzaferro, Vincenzo ;

El-Rayes, Bassel F. ;

Busset, Michele Droz Dit ;

Cotsoglou, Christian ;

Harris, William P. ;

Damjanov, Nevena ;

Masi, Gianluca ;

Rimassa, Lorenza ;

Personeni, Nicola ;

Braiteh, Fadi ;

Zagonel, Vittorina ;

Papadopoulos, Kyriakos P. ;

Hall, Terence ;

Wang, Yunxia ;

Schwartz, Brian ;

Kazakin, Julia ;

Bhoori, Sherrie ;

de Braud, Filippo ;

Shaib, Walid L. .

BRITISH JOURNAL OF CANCER, 2019, 120 (02) :165-171

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