Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques

被引：23

作者：

Bernstein, Hans-Gert ^{[1
]}

Dobrowolny, Henrik ^{[1
]}

Keilhoff, Gerburg ^{[2
]}

Steiner, Johann ^{[1
]}

机构：

[1] Otto v Guericke Univ Magdeburg, Dept Psychiat, Leipziger Str 44, D-39120 Magdeburg, Germany

[2] Otto v Guericke Univ Magdeburg, Inst Biochem & Cell Biol, Leipziger Str 44, D-39120 Magdeburg, Germany

来源：

NEUROCHEMISTRY INTERNATIONAL | 2018年 / 114卷

关键词：

DPP IV; Amyloid; Neurons; Immunohistochemistry; Alzheimer's disease; DPP-4; INHIBITOR; SITAGLIPTIN; DEMENTIA; INSULIN; BETA;

D O I：

10.1016/j.neuint.2018.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：55 / 57

页数：3

共 20 条

[11] DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells
Kornelius, Edy
Lin, Chih-Li
Chang, Hsiu-Han
Li, Hsin-Hua
Huang, Wen-Nung
Yang, Yi-Sun
Lu, Ying-Li
Peng, Chiung-Huei
Huang, Chien-Ning
[J]. CNS NEUROSCIENCE & THERAPEUTICS, 2015, 21 (07) : 549 - 557
[12] Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease
Kosaraju, Jayasankar
Madhunapantula, SubbaRao V.
Chinni, Santhivardhan
Khatwal, Rizwan Basha
Dubala, Anil
Nataraj, Satish Kumar Muthureddy
Basavan, Duraiswamy
[J]. BEHAVIOURAL BRAIN RESEARCH, 2014, 267 : 55 - 65
[13] Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
Kosaraju, Jayasankar
Murthy, Vishakantha
Khatwal, Rizwan Basha
Dubala, Anil
Chinni, Santhivardhan
Nataraj, Satish Kumar Muthureddy
Basavan, Duraiswamy
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2013, 65 (12) : 1773 - 1784
[14] Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals
Lombardi, VRM
García, M
Rey, L
Cacabelos, R
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1999, 97 (1-2) : 163 - 171
[15] Mechanisms of Neurodegeration in Type 2 Diabetes and the Neuroprotective Potential of Dipeptidyl Peptidase 4 Inhibitors
Matteucci, E.
Giampietro, O.
[J]. CURRENT MEDICINAL CHEMISTRY, 2015, 22 (13) : 1573 - 1581
[16] THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD) .2. STANDARDIZATION OF THE NEUROPATHOLOGIC ASSESSMENT OF ALZHEIMERS-DISEASE
MIRRA, SS
HEYMAN, A
MCKEEL, D
SUMI, SM
CRAIN, BJ
BROWNLEE, LM
VOGEL, FS
HUGHES, JP
VANBELLE, G
BERG, L
[J]. NEUROLOGY, 1991, 41 (04) : 479 - 486
[17] Movsisyan N.M., 2013, P YEREVAN STATE U, V1, P36
[18] Changes in Activity of Proline-Specific Peptidases in Rat Model for Dementia of Alzheimer's Type
Nazarova, G. A.
Kolyasnikova, K. N.
Zolotov, N. N.
[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 153 (05) : 674 - 676
[19] Interaction of dipeptydil peptidase IV with amyloid peptides
Sharoyan, Svetlana
Antonyan, Alvard
Mardanyan, Sona
Harutyunyan, Hayk
Movsisyan, Naira
Hovnanyan, Narek
Hovnanyan, Karlen
[J]. NEUROCHEMISTRY INTERNATIONAL, 2013, 62 (08) : 1048 - 1054
[20] Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brain
Spiechowicz, Magdalena
Bernstein, Hans-Gert
Dobrowolny, Henrik
Lesniak, Wieslawa
Mawrin, Christian
Bogerts, Bernhard
Kuznicki, Jacek
Filipek, Anna
[J]. NEUROCHEMISTRY INTERNATIONAL, 2006, 49 (05) : 487 - 493

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