Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy

被引：20
|
作者：
Udono, T
Takahashi, K
Takano, S
Shibahara, S
Tamai, M
机构：
[1] Tohoku Univ, Sch Med, Dept Mol Biol & Appl Physiol, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Sch Med, Dept Ophthalmol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
AMERICAN JOURNAL OF OPHTHALMOLOGY | 1999年 / 128卷 / 06期
关键词：
D O I：
10.1016/S0002-9394(99)00247-0
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001), CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy. (C) 1999 by Elsevier Science:Inc. All rights reserved.
引用
收藏
页码：765 / 767
页数：3
相关论文
共 50 条
  • [41] Levels of pentosidine in the vitreous of eyes with proliferative diabetic retinopathy, proliferative vitreoretinopathy and retinal detachment
    Sanchez-Salorio, M
    Capeans, C
    De-Rojas, V
    Rodriguez, J
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U420 - U420
  • [42] Levels of pentosidine in the vitreous of eyes with proliferative diabetic retinopathy, proliferative vitreoretinopathy and retinal detachment
    Carmela Capeans Tomé
    María Victoria De Rojas Silva
    Javier Rodríguez-García
    Santiago Rodríguez-Segade
    M. Sánchez-Salorio
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2005, 243 : 1272 - 1276
  • [43] MicroRNAs in the Vitreous Humor of Patients with Retinal Detachment and a Different Grading of Proliferative Vitreoretinopathy: A Pilot Study
    Toro, Mario Damiano
    Reibaldi, Michele
    Avitabile, Teresio
    Bucolo, Claudio
    Salomone, Salvatore
    Rejdak, Robert
    Nowomiejska, Katarzyna
    Tripodi, Sarah
    Posarelli, Chiara
    Ragusa, Marco
    Barbagallo, Cristina
    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2020, 9 (06): : 1 - 13
  • [44] INCREASED LIPID PEROXIDE LEVEL AND MYELOPEROXIDASE ACTIVITY IN THE VITREOUS OF PATIENTS SUFFERING FROM PROLIFERATIVE VITREORETINOPATHY
    BOKER, T
    AUGUSTIN, AJ
    BREIPOHL, W
    SPITZNAS, M
    LUTZ, J
    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 1994, 232 (11) : 652 - 656
  • [45] Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative Vitreoretinopathy
    Lei, Hetian
    Velez, Gisela
    Hovland, Peter
    Hirose, Tatsuo
    Kazlauskas, Andrius
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (01) : 42 - 48
  • [46] Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy
    Canataroglu, H
    Varinli, I
    Ozcan, AA
    Canataroglu, A
    Doran, F
    Varinli, S
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2005, 13 (05) : 375 - 381
  • [47] INFLUENCE ON COLLAGEN-METABOLISM OF VITREOUS FROM EYES WITH PROLIFERATIVE VITREORETINOPATHY
    GONZALEZAVILA, G
    LOZANO, D
    MANJARREZ, ME
    RUIZ, VM
    TERAN, L
    VADILLOORTEGA, F
    SELMAN, M
    OPHTHALMOLOGY, 1995, 102 (09) : 1400 - 1405
  • [48] Elevated vitreous nitric oxide levels in patients with proliferative diabetic retinopathy
    Yilmaz, G
    Esser, P
    Kociek, N
    Aydin, P
    Heimann, K
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 130 (01) : 87 - 90
  • [49] Erythropoietin is highly elevated in vitreous fluid of patients with proliferative diabetic retinopathy
    Katsura, Y
    Okano, T
    Matsuno, K
    Osako, M
    Kure, M
    Watanabe, T
    Iwaki, Y
    Noritake, M
    Kosano, H
    Nishigori, H
    Matsuoka, T
    DIABETES CARE, 2005, 28 (09) : 2252 - 2254
  • [50] Chronobiology of proliferative vitreoretinopathy (PVR). A cytological study of 133 vitreous samples
    Martin, F
    Saornil, MA
    de la Rua, ER
    Mayo, A
    Fernandez, N
    Aragon, J
    Pastor, JC
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U1288 - U1288
12345