Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy

被引：20
|
作者：
Udono, T
Takahashi, K
Takano, S
Shibahara, S
Tamai, M
机构：
[1] Tohoku Univ, Sch Med, Dept Mol Biol & Appl Physiol, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Sch Med, Dept Ophthalmol, Aoba Ku, Sendai, Miyagi 9808575, Japan
来源：
AMERICAN JOURNAL OF OPHTHALMOLOGY | 1999年 / 128卷 / 06期
关键词：
D O I：
10.1016/S0002-9394(99)00247-0
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001), CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy. (C) 1999 by Elsevier Science:Inc. All rights reserved.
引用
收藏
页码：765 / 767
页数：3
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