Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy

被引：20

作者：

Udono, T

Takahashi, K

Takano, S

Shibahara, S

Tamai, M

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Biol & Appl Physiol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Dept Ophthalmol, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1999年 / 128卷 / 06期

关键词：

D O I：

10.1016/S0002-9394(99)00247-0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001), CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy. (C) 1999 by Elsevier Science:Inc. All rights reserved.

引用

页码：765 / 767

页数：3

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