Autoxidation Photoredox Catalysis for the Synthesis of 2-Phosphinoylindoles

被引：83

作者：

Wang, Chun-Hai ^{[1
]}

Li, Yong-Hong ^{[1
]}

Yang, Shang-Dong ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 08期

关键词：

PHOSPHORUS-CENTERED RADICALS; VISIBLE-LIGHT PHOTOCATALYSIS; C-P; RING-CLOSURE; DIPHENYLPHOSPHINE OXIDE; MERGING PHOTOREDOX; CYCLIZATION; INDOLE; PHOSPHORYLATION; ALKYNES;

D O I：

10.1021/acs.orglett.8b00722

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the synthesis of 2-phosphinoylindoles through photoredox catalysis without external oxidants has been developed. Promoted by a ruthenium photoredox catalyst, a broad scope of 2-phosphinoylindoles can be synthesized through phosphinoylation/cyclization of diphenylphosphine oxide at room temperature under irradiation without external oxidants. The estrone skeleton isocyan is also an amenable substrate for this cyclization, yielding a molecule that has potential medicinal applications.

引用

页码：2382 / 2385

页数：4

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