Autoxidation Photoredox Catalysis for the Synthesis of 2-Phosphinoylindoles

被引：78
作者：
Wang, Chun-Hai [1 ]
Li, Yong-Hong [1 ]
Yang, Shang-Dong [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 08期
关键词：
PHOSPHORUS-CENTERED RADICALS; VISIBLE-LIGHT PHOTOCATALYSIS; C-P; RING-CLOSURE; DIPHENYLPHOSPHINE OXIDE; MERGING PHOTOREDOX; CYCLIZATION; INDOLE; PHOSPHORYLATION; ALKYNES;
D O I：
10.1021/acs.orglett.8b00722
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new approach to the synthesis of 2-phosphinoylindoles through photoredox catalysis without external oxidants has been developed. Promoted by a ruthenium photoredox catalyst, a broad scope of 2-phosphinoylindoles can be synthesized through phosphinoylation/cyclization of diphenylphosphine oxide at room temperature under irradiation without external oxidants. The estrone skeleton isocyan is also an amenable substrate for this cyclization, yielding a molecule that has potential medicinal applications.
引用
收藏
页码：2382 / 2385
页数：4
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