P-Selectin: An Unpredicted Factor for Deep Vein Thrombosis after Total Hip Arthroplasty

被引：12

作者：

Shi, Dongquan ^{[1
,2
]}

Xu, Xingquan ^{[1
,2
]}

Xu, Zhihong ^{[1
]}

Nakamura, Takahiro ^{[3
,4
]}

Pang, Yong ^{[1
]}

Yao, Chen ^{[1
]}

Wang, Feng ^{[1
]}

Chen, Dongyang ^{[1
]}

Dai, Jin ^{[1
,2
]}

Jiang, Qing ^{[1
,2
]}

机构：

[1] Nanjing Univ, Sch Med, Drum Tower Hosp, Ctr Diag & Treatment Joint Dis, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Model Anim Res Ctr, Australian China Joint Ctr, Lab Bone & Joint Dis, Nanjing 210008, Jiangsu, Peoples R China

[3] Natl Def Med Coll, Math Lab, Tokorozawa, Saitama 3598513, Japan

[4] RIKEN, Ctr Genom Med, Lab Stat Anal, Minato Ku, Tokyo 1088639, Japan

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

VENOUS THROMBOSIS; TISSUE FACTOR; MICROPARTICLES; LEUKOCYTES; PLATELETS; ADHESION;

D O I：

10.1155/2014/783967

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction. Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. Materials and Methods. To confirm the association, a total of 91 subjects who received primary total hip arthroplasty using lateral approach performed by one skilled orthopedic surgeon were studied. All the patients were consecutively enrolled at the Center of Diagnosis and Treatment for Joint Diseases, Drum Tower Hospital affiliated to the Medical School of Nanjing University from 2010 to 2012. All the subjects received venography 3-5 days after operation. We measured P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set. Results. No significant association was detected between P-selectin and DVT (all P values > 0.05). Delta sP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease (P values were 0.03, 0.03, 0.04, and 0.02, resp.). Conclusion. P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty.

引用

页数：6